• Early age at cardiac transplantation may favor successful engrafting with minimal chronic immunosuppression. Fifty-two newborns underwent orthotopic heart transplantation; 47 (90%) survived the operation, and 44 (85%) were late survivors. Actuarial survival was 92% at 1 month, 86% at 1 year, and 84% at 5 years. Forty-four infants who survived 12 weeks and the corresponding 100 rejection episodes were analyzed. Mean follow-up was 2.2 years. The mean number of rejections per year of follow-up was 1.2. No episodes of rejection were identified in six patients. Seven patients had a late rejection episode more than 1 year after transplantation, and only one had a late rejection episode after 2 years. Neonatal cardiac transplantation is effective and durable therapy for uncorrectable heart disease. Intermediate-term results are excellent. Severe rejection is uncommon, and few episodes occur after 1 year of follow-up.
(Arch Surg. 1992;127:1072-1076)
Chiavarelli M, Boucek MM, Nehlsen-Cannarella SL, Gundry SR, Razzouk AJ, Bailey LL. Neonatal Cardiac TransplantationIntermediate-Term Results and Incidence of Rejection. Arch Surg. 1992;127(9):1072-1076. doi:10.1001/archsurg.1992.01420090080011