December 1992

Prognostic Factors in Node-Negative Breast Cancer

Author Affiliations

From the Departments of Surgery (Drs Johnson, Belluco, and Wise) and Pathology (Drs Abou-Azama and Kahn), Long Island Jewish Medical Center, New Hyde Park, NY, and Albert Einstein College of Medicine, Bronx, NY, and the Department of Pathology, University Hospital Medical Center/University of Florida Health Science Center, Jacksonville (Drs Masood and Dee).

Arch Surg. 1992;127(12):1386-1391. doi:10.1001/archsurg.1992.01420120020003

• One hundred patients with node-negative breast cancer were examined to analyze the influence of tumor size, nuclear grade, and DNA content determined by flow cytometry on overall survival. Patients with diploid cancers lived significantly longer than those with aneuploid cancers (126±8 vs 80±11 months). Patients with an S-phase fraction less than 10% lived significantly longer than those with S-phase fractions 10% or greater (122±8 vs 85±10 months). Tumor size had the major impact on survival, and multivariate analysis of variance by the Cox proportional hazards model showed the greatest effect on prognosis. Tumor grade did not significantly influence overall survival.

(Arch Surg. 1992;127:1386-1391)