December 1992

Photodynamic Therapy in the Management of Neoplasms of the Perianal Skin

Author Affiliations

From the Departments of Surgical Oncology (Drs Petrelli, Cebollero, and Rodriguez-Bigas) and Radiation Biology (Dr Mang), Roswell Park Cancer Institute, Buffalo, NY.

Arch Surg. 1992;127(12):1436-1438. doi:10.1001/archsurg.1992.01420120070013

• Perianal extramammary Paget's disease, Bowen's disease, and squamous cell carcinoma are three entities that are very rarely reported. Overall, it is generally accepted that wide surgical excision is adequate treatment except under certain circumstances. Consideration has to be given to invasiveness, metastatic potential, multicentricity, and tendency to recur. We describe four patients who, following unsuccessful multiple attempts at achieving microscopically clear margins with surgical excision, were treated at Roswell Park Cancer Institute with photodynamic therapy with a surface illumination method. With a minimum follow-up of 6 months (more than 1 year in three patients), there have been no recurrences to date.

(Arch Surg. 1992;127:1436-1438)