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March 1993

The Value of Flow Cytometric Analysis in Patients With Gastric Cancer

Author Affiliations

From the Departments of Surgery (Drs Johnson, Belluco, Masood, and Wise) and Pathology (Drs Abou-Azama and Kahn), Long Island (NY) Jewish Medical Center, Long Island Campus for Albert Einstein College of Medicine, and the Department of Pathology, University of Florida Health Sciences Center, Jacksonville (Dr Masood).

Arch Surg. 1993;128(3):314-317. doi:10.1001/archsurg.1993.01420150070013

• Tumors in the gastric cardia and the body/antrum were studied to determine the effect of ploidy and S-phase fractions on patient survival. Forty-two percent of tumors were located in the cardia and 58% in the body/antrum. Nodal metastases occurred more often with cardia tumors than with body/antrum tumors (86% vs 65%). Aneuploidy occurred more frequently in patients with cardia tumors than in patients with body/antrum tumors (39% vs 20%). Metastasis to lymph nodes was more common in patients with aneuploidy than in patients with diploidy (31 % vs 7%). S-phase fractions were not different between aneuploid and diploid tumors. More patients with diploid cancer were alive at 5 years than were patients with aneuploid tumors (90% vs 10%). We conclude that primary cellular differences in gastric tumors of the cardia or body/antrum determine patient survival.

(Arch Surg. 1993;128:314-317)