March 1993

Administration of Dehydroepiandrosterone to Burned Mice Preserves Normal Immunologic Competence

Author Affiliations

From the Division of Cell Biology and Immunology (Drs Araneo, Li, and Daynes) and the Department of Surgery (Dr Shelby and Mr Ku), University of Utah School of Medicine, Salt Lake City.

Arch Surg. 1993;128(3):318-325. doi:10.1001/archsurg.1993.01420150074014

• Burned individuals display a reduced ability to elicit cellular and humoral immune responses and a depression in the in vitro production of certain T-cell lymphokines. Treatment of burned mice with 100 μg of dehydroepiandrosterone within 1 hour after injury resulted in preserving a completely normal capacity to produce T-cell—derived lymphokines and to generate cellular immune responses. In addition, dehydroepiandrosterone-treated thermally injured mice demonstrated an above-normal ability to resist an induced infection with the intracellular pathogen, Listeria monocytogenes. Dehydroepiandrosterone-treated animals also did not exhibit the sustained plasma levels of interleukin 6 that normally accompany thermal injury and infection. Because of its antiglucocorticoid effects and positive immunoregulatory influences, we believe dehydroepiandrosterone to be a beneficial form of therapy for thermally injured individuals.

(Arch Surg. 1993;128:318-325)