• Gastrointestinal involvement with histoplasmosis in patients with the acquired immunodeficiency syndrome is a rare but documented phenomenon. Most patients present with diarrhea, fever, and abdominal pain. We present a case of a woman who tested positive for the human immunodeficiency virus antibody who developed an intestinal perforation due to Histoplasma capsulatum of the ileum. The patient, whose only risk factor was a blood transfusion 8 years earlier, had been previously diagnosed as having disseminated histoplasmosis with gastrointestinal involvement. While receiving oral antifungal treatment (itraconazole), she developed two separate areas of ileal perforation due to H capsulatum. Complications from gastrointestinal involvement with histoplasmosis, such as perforation, should be considered in patients infected with the human immunodeficiency virus with signs and symptoms suggesting abdominal disease.
(Arch Surg. 1993;128:464-466)
Heneghan SJ, Li J, Petrossian E, Bizer LS. Intestinal Perforation From Gastrointestinal Histoplasmosis in Acquired Immunodeficiency SyndromeCase Report and Review of the Literature. Arch Surg. 1993;128(4):464-466. doi:10.1001/archsurg.1993.01420160106018