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November 1993

Cardiac PreconditioningInduction of Endogenous Tolerance to Ischemia-Reperfusion Injury

Author Affiliations

From the Department of Surgery, University of Colorado Health Sciences Center, Denver.

Arch Surg. 1993;128(11):1208-1211. doi:10.1001/archsurg.1993.01420230036005

Cardiac preconditioning is a phenomenon by which a brief exposure to ischemia renders the heart more tolerant of a subsequent sustained ischemic insult. Understanding the mechanism involved may allow pharmacologic access to this protective state before cardiopulmonary bypass surgery and transplantation. We discuss herein the preconditioning phenomenon, the potential mechanisms involved, and the therapeutic implications of cardiac preconditioning.

(Arch Surg. 1993;128:1208-1211)