To clarify the relationship between the noninvasive evaluation of hepatic mitochondrial function, the redox tolerance test, and cytochrome c oxidase activity of the liver, focusing on surgical risk in hepatic resection.
Six-month randomized clinical trial.
Inpatients in surgical department.
Forty patients who underwent hepatic resection (n=36) and other abdominal operations (n=4).
Preoperative, noninvasive: The redox tolerance test, which measures the changes in arterial ketone body ratio in response to 75 g of oral glucose loading. Intraoperative, invasive: Cytochrome c oxidase activity and energy charge of the liver.
Main Outcome Measure:
Correlation of the index in the redox tolerance test (RTI) with cytochrome c oxidase activity, both of which predict the postoperative course.
The RTI values were negatively correlated with the maximal velocity (Vmax) and Michaelis constant (Km) values of cytochrome c oxidase activity. The maximal velocity and Michaelis constant values in patients with RTI values above or equal to 0.5 (group A, n=29) were significantly lower than those in patients with RTI values below 0.5 (group B, n=11). Eight (72.7%) of 11 patients in group B experienced postoperative complications.
The RTI is a noninvasive method of assessing the hepatic energy metabolism and can be a useful index for evaluating surgical risk in hepatectomy.(Arch Surg. 1994;129:303-308)
Ueda J, Mori K, Sakai Y, Tanaka A, Katayama T, Maki A, Shimahara Y, Yamaoka Y, Ozawa K. Noninvasive Evaluation of Cytochrome c Oxidase Activity of the LiverIts Prognostic Value for Hepatic Resection. Arch Surg. 1994;129(3):303-308. doi:10.1001/archsurg.1994.01420270079018