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March 1994

Adult Pancreatic NesidioblastosisUnusual Presentations of a Rare Entity

Author Affiliations

From the Departments of Gastroenterologic and General Surgery (Drs Farley and van Heerden) and Laboratory Medicine and Pathology (Dr Myers), Mayo Clinic and Mayo Foundation, Rochester, Minn.

Arch Surg. 1994;129(3):329-332. doi:10.1001/archsurg.1994.01420270107022

Adult nesidioblastosis remains an uncommon and poorly understood condition creating both diagnostic and therapeutic dilemmas for clinicians. Despite the totipotent nature of hyperplastic pancreatic cells, nearly all accounts of nesidioblastosis described patients with symptoms of hypoglycemia. We herein describe two unique patients with adult nesidioblastosis with gastrin and pancreatic polypeptide secretion. Surgical resection rendered these two patients free of disease.

(Arch Surg. 1994;129:329-332)