July 1994

Histologic Changes After Stenting of the Pancreatic Duct

Author Affiliations

From the Departments of Surgery (Drs Alvarez and Reber) and Pathology (Dr Robert), University of California—Los Angeles School of Medicine; the Surgical Service, Sepulveda (Calif) Veterans Affairs Medical Center (Drs Alvarez and Reber); and the Division of Gastroenterology, Indiana University Medical Center, Indianapolis (Dr Sherman).

Arch Surg. 1994;129(7):765-768. doi:10.1001/archsurg.1994.01420310097018

The placement of stents has been proposed as a possible modality to treat pancreatic diseases. Ductal changes observed on endoscopic retrograde cholangiopancreatography during stenting are believed to be reversible when the stents are removed. We describe a patient with normal anatomy on baseline pancreatograms who underwent endoscopic sphincterotomy, followed by stent placement for 9 months. Symptoms progressed, leading to a pancreaticoduodenectomy. Histologic evaluation of the head of the pancreas revealed more extensive inflammatory changes in the duct and parenchyma drained by the stent. This suggests that stent-induced changes noted on pancreatography correspond to parenchymal changes that may be severe and irreversible.

(Arch Surg. 1994;129:765-768)