May 1996

A Prospective Study of Carbon Dioxide—Digital Subtraction vs Standard Contrast Arteriography in the Evaluation of the Renal Arteries

Author Affiliations

From the Department of Surgery, University of Southern California School of Medicine, Los Angeles.

Arch Surg. 1996;131(5):503-508. doi:10.1001/archsurg.1996.01430170049008

Objective:  To compare carbon dioxide—digital subtraction arteriographic (CO2-DSA) images of renal artery anatomy with standard iodinated contrast arteriographic (ICA) images.

Design:  One hundred patients with vascular disease who required abdominal aortography were evaluated by both CO2-DSA and ICA modalities. Two blinded readers interpreted arteriograms for the degree of renal artery stenosis, and a third reader was employed to resolve differences in reader interpretations.

Setting:  University medical center.

Main Outcome Measures:  The sensitivity, specificity, negative predictive value, positive predictive value, and accuracy were calculated for the ability of CO2-DSA to demonstrate a 60% or greater stenosis of the main renal artery; k values for CO2-DSA and ICA were calculated to assess intraobserver variability.

Results:  Of the 200 main renal arteries imaged, 17 (9 by means of CO2-DSA, 8 by means of ICA) were eliminated because of inadequate visualization of the renal artery. In identifying a renal artery stenosis of 60% or greater, CO2DSA had a sensitivity of 0.83, specificity of 0.99, positive predictive value of 0.94, and negative predictive value of 0.98. The overall accuracy was 0.97. The k statistic was 0.75 for CO2-DSA and 0.70 for ICA, hence, the variation in the interpretations of CO2-DSA and ICA were comparable.

Conclusion:  Images by means of of CO2-DSA accurately reflect pathologic changes in renal arteries and are thus useful in the diagnosis of clinically occult occlusive renal artery disease in patients at risk of contrast medium—related nephrotoxicity.(Arch Surg. 1996;131:503-508)