To determine a rational approach to heparin dosing for thromboembolism prophylaxis.
Three commonly used heparin dosing regimens were identified: (1) standard low-dose heparin (5000 U administered subcutaneously 2-3 times per day); (2) adjusted-dose heparin (adequate to elevate the activated partial thromboplastin time to 5 seconds above the upper limit of normal); and (3) low-molecular-weight heparin (30 mg subcutaneously twice daily without monitoring).
Adjusted-dose heparin thromboembolism prophylaxis is both the safest and most reliable method currently available.Arch Surg. 1996;131:1069-1073
Owings JT, Blaisdell FW. Low-Dose Heparin Thromboembolism Prophylaxis. Arch Surg. 1996;131(10):1069-1073. doi:10.1001/archsurg.1996.01430220063014