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We would like to thank Drs Mullins and Theodoro for their comments and interest in on our recent article.1 There are several statements, however, that need to be addressed.
The authors question the internal validity of the study design. Internal validity errors concern instances in which a study design fails to address the narrowest of research questions. We feel the basic study question was answered and clearly stated in the introduction.
Cotton BA, Guillamondegui OD. Lack of Evidence for Adrenal Insufficiency After Single-Dose Etomidate—Reply. Arch Surg. 2008;143(8):809. doi:10.1001/archsurg.143.8.809-a