[Skip to Content]
Sign In
Individual Sign In
Create an Account
Institutional Sign In
OpenAthens Shibboleth
[Skip to Content Landing]
Article
December 1967

Hemodynamics of Endotoxin Shock in the Dog

Author Affiliations

Buffalo, NY
From the Department of Surgery, State University of New York at Buffalo, and the Edward J. Meyer Memorial Hospital, Buffalo. Doctor Dedichen was a Buswell fellow in surgical research; he is now at the Surgical Department A, Rikshospitalet, Oslo.

Arch Surg. 1967;95(6):1013-1016. doi:10.1001/archsurg.1967.01330180161027
Abstract

SHOCK induced by intravenous injection of Escherichia coli endotoxin is a widely used model in experimental shock work because it resembles clinical septic shock in a variety of respects1 and is an easy and relatively reproducible way of incuding hypotension.

However, comprehensive reports on hemodynamic changes in endotoxin shock are few, results are contradictory, and relatively little is known about regional blood flow and vascular resistance changes.

As adequate understanding of the hemodynamic derangements is an obvious requirement for rational treatment, the purpose of this investigation was to measure cardiac output as well as blood flow in the renal, superior mesenteric, and femoral arteries in order to document changes in regional blood flows and vascular resistances in endotoxin shock.

Materials and Methods  Ten adult, healthy, mongrel dogs of both sexes weighing 21.8 to 33.5 kg (48 to 73.8 lb) were used for the experiment. Anesthesia was induced with intravenously

References
1.
Gilbert, R.P.:  Mechanisms of the Hemodynamic Effects of Endotoxin , Physiol Rev 40:245-279, 1960.
2.
Rossing, R.G., and Cain, S.M.:  A Nomogram Relating P02, pH, Temperature and Hemoglobin Saturation in the Dog , J Appl Physiol 21:195-201, 1966.
3.
Kuida, H., et al:  Effect of Gram-Negative Endotoxin on Pulmonary Circulation , Amer J Physiol 192:335-344, 1958.
4.
Tikoff, G.; Kuida, H.; and Chiga, M.:  Hemodynamic Effects of Endotoxin in Calves , Amer J Physiol 210:847-853, 1966.
5.
Weil, M.H., et al:  Studies on the Circulatory Changes in the Dog Produced by Endotoxin From Gram-Negative Micro-organisms , J Clin Invest 35:1191-1198, 1956.Article
6.
Hinshaw, L.B., et al:  Changes in Total Peripheral Resistance in Endotoxin Shock , Proc Soc Exp Biol Med 108:24-27, 1961.Article
7.
Lillehei, R.C., and MacLean, L.D.:  The Intestinal Factor in Irreversible Endotoxin Shock , Ann Surg 143:513-542, 1958.Article
×