[Skip to Content]
Sign In
Individual Sign In
Create an Account
Institutional Sign In
OpenAthens Shibboleth
[Skip to Content Landing]
Article
January 1968

Histoplasma Endocarditis

Author Affiliations

Ann Arbor, Mich
From the Department of Pathology, University of Michigan, Ann Arbor.

Arch Surg. 1968;96(1):158-162. doi:10.1001/archsurg.1968.01330190160034
Abstract

ENDOCARDITIS caused by Histoplasma capsulatum is rare. Only 14 cases with complete necropsy have been recorded to date.1-14 Two other patients with Histoplasma endocarditis have been cited in the literature; one of these recovered following therapy with amphotericin B.15 the other patient's necropsy was limited to an examination of the heart.16 Prior to this writing, a prosthetic valve of the heart has never been reported to be the site of fungal endocarditis.

It is the intent of this report to present the clinical and pathological findings in two patients with Histoplasma endocarditis, one of whom had his disease originating on a cardiac valve prosthesis. The observations derived from study of these patients are correlated with those of the earlier documented cases of Histoplasma endocarditis.

Report of Cases 

Case 1.  —A 43-year-old plasterer was transferred to the University of Michigan Medical Center in March 1963, after hospitalization for

References
1.
Beamer, P.R.; Reinhard, E.H.; and Goodof, A.I.:  Vegetative Endocarditis Caused by Higher Bacteria and Fungi , Amer Heart J 29:99-112, 1945.Article
2.
Berman, B.:  Histoplasmosis Endocarditis , J Sinai Hosp 9:4-8, 1960.
3.
Binford, C.H.:  Histoplasmosis: Tissue Reactions and Morphologic Variations , Amer J Clin Path 25:25-36, 1955.
4.
Broders, A.C., et al:  Histoplasmosis Producing Vegetative Endocarditis , JAMA 122:489-492, 1943.Article
5.
Fawell, W.N.; Browns, H.L.; and Ernstene, A.C.:  Vegetative Endocarditis Due to Histoplasma capsulatum , Cleveland Clin Quart 18:305-309, 1951.Article
6.
Gerber, H.J.; Schoonmaker, F.W.; and Vazquez, M.D.:  Chronic Meningitis Associated with Histoplasma Endocarditis , New Eng J Med 275:74-76, 1966.Article
7.
Hurst, M.D.; Weodek, G.K.; and Parker, J.O.:  Histoplasma Endocarditis , Amer J Med 32:460-466, 1962.Article
8.
Kemper, J.W., and Bloom, H.J.:  Histoplasmosis: Report of a Case , J Oral Surg 2:167-172, 1944.
9.
Korns, M.E.:  Coincidence of Mycotic (Histoplasma capsulatum) Vegetative Endocarditis of the Mitral Valve and the Lutembaher Syndrome , Circulation 32:589-592, 1965.Article
10.
Merchank, R.K., et al:  Fungal Endocarditis: Review of the Literature and Report of Three Cases , Ann Intern Med 48:242-266, 1958.Article
11.
Palmer, R.L.; Geraci, J.E.; and Thomas, B.J.:  Histoplasma Endocarditis , Arch Intern Med 110: 359-365, 1962.Article
12.
Parsons, R.J., and Zarafonetis, C.J.D.:  Histoplasmosis in Man: Report of Seven Cases and Review of 71 Cases , Arch Intern Med 75:1-23, 1945.Article
13.
Sulack, M.H.:  Clincopathological Conference , U S Armed Forces Med J 8:70-81, 1957.
14.
Zimmerman, L.E.:  Candida and Aspergillus Endocarditis , Arch Path 50:591-605, 1950.
15.
Derby, B.M.; Coolidge, K.; and Rogers, D.E.:  Histoplasma Capsulatum Endocarditis with Major Arterial Embolism , Arch Intern Med 110:63-69, 1962.Article
16.
Moore, M.:  Morphologic Variation in Tissue of the Organism of Blastomycosis and of Histoplasmosis , Amer J Path 31:1049-1057, 1955.
17.
Loosli, C.G.:  Histoplasmosis , J Chronic Dis 5:473-488, 1957.Article
18.
Nelson, N.H.; Goodman, H.L.; and Oster, H.C.:  The Association of Histoplasmosis and Lymphoma , Amer J Med Sci 233:56-65, 1957.Article
19.
Gruhn, J.G., and Sanson, J.:  Mycotic Infiltrations in Leukemic Patients at Autopsy , Cancer 16:61-73, 1963.Article
20.
Andriole, U.T., et al:  Candida Endocarditis Clinical and Pathological Studies , Amer J Med 32: 251-285, 1962.Article
21.
Akbarian, M.; Salfelder, K.; and Schwarz, J.:  Experimental Histoplasmic Endocarditis , Arch Intern Med 114:789-791, 1964.
22.
Herr, R., et al:  Special Problems Following Valve Replacement: Embolus, Leak, Infection, and Red Cell Damage , Ann Thorac Surg 1:403-415, 1965.Article
×