[Skip to Content]
Sign In
Individual Sign In
Create an Account
Institutional Sign In
OpenAthens Shibboleth
[Skip to Content Landing]
Article
April 1968

The Effect of Bile Diversion on Induced Hypercholesterolemia

Author Affiliations

Omaha
From the Department of Surgery, Creighton University School of Medicine and the Surgical Research Laboratories, Creighton Memorial St. Joseph's Hospital, Omaha. Dr. Keig is presently at the Bremerton Naval Hospital, Bremerton, Wash. Dr. McKain is at the Magic Valley Community Hospital, Twin Falls, Idaho.

Arch Surg. 1968;96(4):613-618. doi:10.1001/archsurg.1968.01330220129021
Abstract

HYPERCHOLESTEROLEMIA is considered a major denominator in coronary atherosclerosis, and in view of the unfortunately high incidence of coronary atherosclerosis, methods of control of hypercholesterolemia should be in demand. As will be demonstrated in the following report of our investigations, this can be accomplished very effectively by biliary diversion.

Method  Hypercholesterolemia was produced in 20 adult mongrel dogs after baseline serum cholesterol levels and weights had been established. The hypercholesterolemic state was induced by performing a near-total thyroidectomy complemented by 100 mg of propylthiouracil a day, along with a daily diet containing 20 gm of cholesterol and 40 gm of animal fat. Weekly weights and serum cholesterol values were obtained, and each animal was followed up until stable levels were observed. At this point, they were placed into one of the four groups described below.A biliary diversion procedure was performed in three of the groups. The technique employed, as

References
1.
Mann, F.D., and Williamson, C.S.:  The Experimental Production of Peptic Ulcer , Ann Surg 77:409, 1923.Article
2.
Kritchevsky, D.: Cholesterol , New York: John Wiley & Sons, Inc., 1958.
3.
Schaefer, L.E., et al:  Genetic Studies on Hypercholesteremia: Frequency in Hospital Population and in Families of Hypercholesteremic Index Patients , Amer Heart J 46:99-116, 1953.Article
4.
Lewis, L.A., et al:  "Short-Circuiting" of the Small Intestine: Effect on Concentration of Serum Cholesterol and Lipoproteins , JAMA 182:77-79, 1962.Article
5.
Scott, H.W., Jr., et al:  Prevention of Experimental Atherosclerosis by Ileal Bypass: 20 Percent Cholesterol Diet and I131 Induced Hypothyroidism in Dogs , Ann Surg 163:795-807, 1966.Article
6.
Buchwald, H., and Gebhard, R.L.:  Effect of Intestinal Bypass on Cholesterol Absorption and Blood Levels in the Rabbit . Amer J Physiol 207:567-572, 1964.
7.
Buchwald, H., and Varco, R.L.:  Ileal Bypass in Patients With Hypercholesterolemia and Atherosclerosis , JAMA 196:627-630, 1966.Article
8.
Byers, S.O., et al:  Observations Concerning the Production and Excretion of Cholesterol in Mammals: XI. The Intestinal Site of Absorption and Excretion of Cholesterol , Amer J Physiol 175:375-379, 1953.
9.
Cook, R.P.: Cholesterol , New York, Academic Press, Inc., 1958.
10.
DePalma, R.G., et al:  Effect of Common Duct Drainage on Serum Cholesterol , Surg Forum 16:388-389, 1965.
11.
Buchwald, H.:  The Effect of Ileal Bypass on Atherosclerosis and Hypercholesterolemia in the Rabbit , Surgery 58:22-36, 1965.
12.
Scott, H.W., Jr., et al:  Effects of Bypass of the Distal Fourth of the Small Intestine on Experimental Hypercholesterolemia and Atherosclerosis in Rhesus Monkeys , Surg Gynec Obstet , 125:3, 1967.
13.
Buchwald, H., and Varco, R.L.:  Partial Ileal Bypass for Hypercholesterolemia and Atherosclerosis , Surg Gynec Obstet 124:1231, 1967.
×