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November 1968

Solid Carcinoma With Amyloid of the Thyroid Gland—a Clinicopathologic EntityReview of Ten Cases

Author Affiliations

Petach-Tikvah; Tel-Aviv, Israel
From the departments of pathology and otolaryngology, Beilinson Hospital, Petach-Tikvah, Israel. Dr. Shanon is now at the Ichilov Hospital, Tel-Aviv, Israel.

Arch Surg. 1968;97(5):774-779. doi:10.1001/archsurg.1968.01340050114016

In 1959, Hazard et al1 described a clinicopathologic entity, distinct in the pleomorphic group of thyroid neoplasms. The tumor was classified as medullary (solid) carcinoma containing amyloid. At about the same time, we had the opportunity to observe a similar growth. The morphological and clinical peculiarities of our case indicated a survey of histories of patients with thyroid tumors. The following criterion was kept in mind: each patient with "anaplastic thyroid neoplasm" who survived for more than one year, regardless of the nature of therapy, calls for a pathological reevaluation. Seven additional cases were found and two other patients were seen recently, thus bringing our total experience to ten cases (Table).

Report of Cases  Case 1.—A 46-year-old woman was admitted to our department in August 1960 because of enlarged cervical lymph nodes. In 1945, she had first noticed a mass in her neck. Examination at that time revealed a

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