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December 1968

Blood Tests and Doppler Flowmeter ExaminationCompared With Phlebograms in Venous Thrombosis

Author Affiliations

New Haven, Conn
From the departments of surgery (Dr. Hume), radiology (Dr. Glancy), and public health (Dr. Chan), Yale University School of Medicine and Yale-New Haven Medical Center, New Haven, Conn.

Arch Surg. 1968;97(6):894-898. doi:10.1001/archsurg.1968.01340060072007

MORE accurate diagnosis of venous thrombosis is needed for many reasons, viz, autopsy studies show that fatal pulmonary embolism occurs without overt signs of venous thrombosis. No accurate screening method is available to predict embolism in asymptomatic cases. Prophylactic anticoagulants are recommended for certain high-risk individuals, eg, postoperative or posttraumatic cases, those having congestive heart failure or myocardial infarction—but in some of these, relative or absolute contraindication to anticoagulants exists. In such circumstances a measurement of the risk of thrombosis would be useful. A small but definite risk of venous thrombosis and pulmonary embolism is involved in the use of anovulatory hormones. Changes in certain blood tests which do occur during the use of these drugs may permit the risk in each individual to be defined. New drugs which act on blood platelets are being proposed for the treatment of thrombosis. Changes in blood tests characteristic of thrombosis have been

Hume, M., and Chan, Y.K.:  Examination of the Blood in the Presence of Venous Thrombosis , JAMA 200:747-750 ( (May 29) ) 1967.Article
Hume, M., and Chan, Y.K.: Estimation of the risk of Thromboembolism by Blood Tests and Clinical Data, Proceedings of the NRC Task Force on Thrombosis Conference in Washington, November 1967, to be published.
Sigel, B., et al:  A Doppler Ultrasound Methcd for Diagnosing Lower Extremity Venous Disease , Surg Gynec Obstet 127:339, 1968.
Parfentjev, I.A.; Johnson, M.L.; and Cliffton, E.E.:  The Determination of Plasma Fibrinogen by Turbidity With Ammonium Sulfate , Arch Biochem 46:470-480 ( (Sept) ) 1953.Article