[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address Please contact the publisher to request reinstatement.
Sign In
Individual Sign In
Create an Account
Institutional Sign In
OpenAthens Shibboleth
[Skip to Content Landing]
January 1969

Inhibition of Pepsin Secretion by Acid in the Intestine

Author Affiliations

From the Harrison Department of Surgical Research (Drs. Copeland and Miller) and Department of Physiology (Dr. Smith), School of Medicine, University of Pennsylvania, Philadelphia. Dr. Smith is now at Cornell Medical Center, White Plains, NY.

Arch Surg. 1969;98(1):115-116. doi:10.1001/archsurg.1969.01340070133030

Following meal, pepsin output from a Heidenhain pouch (HP) is depressed below basal levels, while pepsin output from a Pavlov pouch (PP) increases markedly.1-3 A possible explanation of this difference may be that vagal denervation renders the peptic cells (chief cells) more vulnerable to intestinal inhibitory mechanisms activated by feeding. Fat in the intestine4,5 is known to inhibit pepsin secretion stimulated by a meat meal, histamine, or pilocarpine, but the effect is greater in PP than in HP.5 Acid in the intestine inhibits pepsin secretion from PP, but in the one HP studied, there was no certain effect. To examine the problem further, we diverted endogenous acid from the upper small bowel segments. The effect of the diversion of acid on pepsin secretion was evaluated in HP stimulated by varying doses of histamine.

Materials and Methods  In three healthy, male, mongrel dogs weighing 19 to 21.5 kg,

Schofield, B.:  The Pattern of Pepsin Secretion in Innervated and Heidenhain Gastric Pouches in Dogs , Gastroenterology 33:714-729 ( (Nov) ) 1957.
Schofield, B.:  The Inhibition of Pepsin Output in Separated Gastric Pouches in Dogs Following Feeding, and its Correlation With Motility Changes , Gastroenterology 37:169-181 ( (Aug) ) 1959.
Long, J.F., and Brooks, F.P.:  The Comparative Acid and Pepsin Response to Histamine, Insulin, Hypoglycemia, and Feeding in Dogs With Vagally Innervated Gastric Pouches , Quart J Exp Physiol 50:256-262, 1965.
Long, J.F.; Brooks, F.P.; and Sandweiss, D.J.:  A Comparison of Fats of Varying Saturation as Inhibitors of Canine Gastric Secretion , Gastroenterology 45:638-643 ( (Nov) ) 1963.
Grossman, M.I., et al:  Pepsin Secretion and Enterogasterone , Amer J Physiol 141:281-288 ( (April) ) 1944.
Friedman, M.H.F., et al:  Stimulation of Pepsin Secretion by Means of Acid in the Intestine , Amer J Physiol 140:708-712 ( (Feb) ) 1944.
Bucher, R.G.; Grossman, M.I.; and Ivy, A.C.:  A Pepsin Method: The Role of Dilution in the Determination of Peptic Activity , Gastroenterology 5:501-522 ( (Dec) ) 1945.
Goldstein, A.: Biostatistics: An Introductory Text , New York: The Macmillan Co., 1964, p 51.
Wormsely, K.G., and Grossman, M.I.:  Inhibition of Gastric Acid Secretion by Secretin and by Endogenous Acid in the Duodenum , Gastroenterology 47:72-81 ( (July) ) 1964.
Konturek, S., and Grossman, M.I.:  Localization of the Mechanism for Inhibition of Gastric Secretion by Acid in the Intestine , Gastroenterology 49:74-78 ( (July) ) 1965.
Sabsai, B.I.:  The Effect of Extensive Resections of the Small Intestine on the Enzyme-Secretory Function of the Stomach , Biull Eksp Biol Med 59:42-47, 1965.Article