[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address 54.147.241.171. Please contact the publisher to request reinstatement.
Sign In
Individual Sign In
Create an Account
Institutional Sign In
OpenAthens Shibboleth
[Skip to Content Landing]
Article
February 1969

Effects of Vasoactive Drugs on Oxygen Consumption in Endotoxin Shock

Author Affiliations

Jackson, Miss
From the Department of Surgery, University of Mississippi Medical Center, Jackson, Miss.

Arch Surg. 1969;98(2):189-193. doi:10.1001/archsurg.1969.01340080081016
Abstract

Recent investigations of the various shock states have focused on metabolic changes and especially changes in oxygen consumption. We previously reported a study of oxidative metabolism in experimental endotoxin shock employing a continuous oxygen consumption recorder.1 It was found that during the fourth hour of shock the restoration of the hemodynamic parameters by balanced fluid therapy did not correct the deficiency in oxygen uptake. The objective of the present study was to examine the effect of several clinically employed vasoactive drugs upon oxygen consumption in experimental endotoxin shock. Lerarterenol (norepinephrine) bitartrate was selected as a vasoconstrictor agent, phenoxybenzamine (Dibenzyline) as an alpha receptor blocking agent, and isoproterenol (Isuprel) as an inotropic vasodilator.

Materials and Methods  Forty-three adult mongrel dogs were used, and changes in oxygen consumption, cardiac output, central blood volume, mean arterial blood pressure, hematocrit, arterial and venous oxygen saturation, arterial lactate and pyruvate, and arterial pH were

References
1.
Guyton, A.C., and Farish, C.A.:  A Rapidly Responding Continuous Oxygen Consumption Recorder , J Appl Physiol 14:143-145 ( (Jan) ) 1959.
2.
Anas, P.; Neely, W.A.; and Hardy, J.D.:  Relation of Oxygen Consumption to Hemodynamic Changes in Experimental Endotoxin Shock , Surg Gynec Obstet 126: 754-760 ( (April) ) 1968.
3.
Broder, G., and Weil, M.M.:  Excess Lactate: An Index of Reversibility in Human Patients , Science 143:1457-1459 ( (March 22) ) 1964.Article
4.
Bloch, J.H.; Pierce, C.H.; and Lillehei, R.C.:  Adrenergic Blocking Agents in the Treatment of Shock , Ann Rev Med 17:483-503, 1966.Article
5.
Udhoji, V.N., and Weil, M.H.:  Circulatory Effects of Angiotensin, Levarterenol and Metaraminol in the Treatment of Shock , New Eng J Med 270:501-505 ( (May 5) ) 1964.Article
6.
Hakstian, R.W.; Hampson, L.G.; and Gurd, F.N.:  Pharmocological Agents in Experimental Hemorrhagic Shock , Arch Surg 83:335-347 ( (Sept) ) 1961.Article
7.
Smith, L.L.; Muller, W.; and Hinshaw, D.:  The Management of Experimental Endotoxin Shock , Arch Surg 89:630-635 ( (Oct) ) 1964.Article
8.
Rush, B.F.:  Treatment of Experimental Shock: Comparison of the Effects of Norepinephrine, Dibenzyline, Dextran, Whole Blood and Balanced Saline Solutions , Surgery 61:938-944 ( (June) ) 1967.
9.
Alican, F., and Hardy, J.D.:  Sympatho-adrenal System in Endotoxin Shock , Surg Forum 13:8-10, 1962.
10.
Chien, S.:  Role of Sympathetic Nervous System in Hemorrhage , Physiol Rev 47:215-288 ( (April) ) 1967.
11.
Gilbert, R.P., and Hohf, R.:  Hemodynamic Basis of Norepinephrine Shock , Pro Soc Exp Biol Med 116:43-45 ( (May) ) 1964.Article
12.
Smith, E.E., and Crowell, J.W.:  Effect of Hemorrhagic Hypotension on Oxygen Consumption of Dogs , Amer J Physiol 207:647-649 ( (Sept) ) 1964.
13.
Johnson, D.G., and Parkins, W.M.:  Effects of Isoproterenol and Levarterenol on Blood Flow and Oxygen Use in Hemorrhagic Shock , Arch Surg 92:277-286 ( (Feb) ) 1966.Article
14.
Griffith, E.R., Jr.:  Fact and Theory Regarding the Calorigenic Action of Adrenaline , Physiol Rev 31:151-179 ( (April) ) 1951.
15.
Poyart, C., and Nahas, G.G.:  Inhibition of Catecholamine—Induced Calorigenesis and Lipolysis by Hepercapnic Acidosis , Amer J Physiol 211:161-168 ( (July) ) 1966.
16.
Anderson, R.W., et al:  Phenoxybenzamine in Septic Shock , Ann Surg 165:341-350 ( (March) ) 1967.Article
17.
Eckenhoff, J.E., and Cooperman, L.H.:  The Clinical Application of Phenoxybenzamine in Shock and Vasoconstrictive States , Surg Gynec Obstet 121:483-490 ( (Sept) ) 1965.
18.
Abrams, J.S., et al:  Rapid Volume Expansion and Phenoxybenzamine in Endotoxin Shock , Surg Forum 16:5-7, 1965.
19.
Rush, B.F., Jr.; Rosenberg, J.C.; and Spencer, F.C.:  Effect of Dibenzyline Treatment on Cardiac Dynamics and Oxidative Metabolism in Hemorrhagic Shock , Ann Surg 162:1013-1016 ( (Dec) ) 1965.Article
20.
Baue, A.E.; Johnson, D.G.; and Parkins, W.M.:  Blood Flow and Oxygen Consumption With Adrenergic Blockade in Hemorrhagic Shock , Amer J Physiol 211:354-360 ( (Aug) ) 1966.
21.
Bradley, E.C., and Weil, M.M.:  Treatment of Circulation Shock With Isoproterenol , Calif Med 106:10 ( (Jan) ) 1967.
22.
Kardas, G.G.:  Isoproterenol in the Treatment of Shock Due to Bacteremia With Gram Negative Pathogens , New Eng J Med 274:868-873 ( (April 21) ) 1966.Article
23.
Siegel, J.H., and Fabian, H.:  Therapeutic Advantages of an Inotropic Vasodilator in Endotoxin Shock , JAMA 200:696-704 ( (May 22) ) 1967.Article
×