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May 1969

Intestinal Resection and Gastric Secretion in Dogs With Antrectomy

Author Affiliations

Columbia, Mo
From the Department of Surgery, University of Missouri School of Medicine, Columbia.

Arch Surg. 1969;98(5):645-646. doi:10.1001/archsurg.1969.01340110137018

Previous work from this laboratory1 established that massive small bowel resection, or intestinal bypass, produces a striking increase in the secretion of acid from Heidenhain pouches in dogs. This observation has been confirmed and extended by similar, though not identical, experiments in other laboratories.2-7 Although previous attempts have been made to clarify the possible role of the gastric antrum in this postenterectomy hypersecretion, the issue has not been settled. The present study was undertaken to determine if postenterectomy hypersecretion occurs in the absence of the antrum.

Method  Eight mongrel dogs of both sexes, varying in weight between 12.2 and 18.4 kg were used. Operations were performed aseptically under pentobarbital sodium anesthesia. The animals were maintained on a standard kennel ration and were provided a measured amount of food at the same time each day. Food pans remained in the cages for one hour only and the residual food,

Landor, J.H., and Baker, W.K.:  Gastric Hypersecretion Produced by Massive Small Bowel Resection in Dogs , J Surg Res 4:518-522, 1964.Article
Frederick, P.L.; Sizer, J.S.; and Osborne, M.P.:  Relation of Massive Bowel Resection to Gastric Secretion , New Eng J Med 272:509-514, 1965.Article
Westerheide, R.L.; Elliott, D.W.; and Hardacre, J.M.:  The Potential of the Upper Small Bowel in Regulating Acid Secretion , Surgery 58:73-81, 1965.
Reul, G., and Ellison, E.:  Effect of 75% Distal Small Bowel Resection on Gastric Secretion , Amer J Surg 111:772-775, 1966.Article
Osborne, M.P., et al:  Mechanism of Gastric Hypersecretion Following Massive Intestinal Resection: Clinical and Experimental Observations , Ann Surg 164:622-631, 1966.Article
Grundberg, A.B.; Lopez, A.S.; and Dragstedt, L.R.:  II. Effect of Intestinal Reversal and Massive Resection on Gastric Secretion , Arch Surg 94:326-329, 1967.Article
Santillana, M., et al: Changes in Gastric Acid Secretion Following Resection or Exclusion of Different Segments of the Small Intestine, Surgery, to be published.
Kerr, G.; Elliott, D.W.; and Endahl, G.L.:  Effect of Antrectomy on Gastric Acid Hypersecretion Induced by Isolation of the Proximal Small Bowel , Amer J Surg 115:157-163, 1968.Article
Olbe, L.:  Potentiation of Sham Feeding Response in Pavlov Pouch Dogs by Subthreshold Amounts of Gastrin With and Without Acidification of Denervated Antrum , Acta Physiol Scand 61:244-254, 1964.Article
Olbe, L.:  Effect of Resection of Gastrin-Releasing Regions on Acid Response to Sham Feeding and Insulin Hypoglycemia in Pavlov Pouch Dogs , Acta Physiol Scand 62:169-174, 1964.Article
Stavney, L.S., et al:  Parietal Cell Reactivity , Surg Gynec Obstet 118:1269-1272, 1964.