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May 1969

Gastrin Inhibition of Histamine-Induced Gastric Secretion

Author Affiliations

Jackson, Miss
From the Department of Surgery, University of Mississippi Medical Center, Jackson. Dr. Wilken is now at the University of Edinburgh, Scotland.

Arch Surg. 1969;98(5):647-651. doi:10.1001/archsurg.1969.01340110139019

Uvnas,1 in the 1940's was the first to note a decreasing response to repeated stimulation with crude gastrin extracts, but this effect was thought to be due to a contaminating inhibitory factor. The inhibition of gastric acid secretion by extracts containing gastrin was first demonstrated clearly by Gillespie and Grossman2 in 1963 and confirmed by Gregory and Tracy3 (1964) using a highly purified preparation. The mechanism of this dual action of gastrin, also possessed by the synthetic pentapeptide has not been adequately explained. The ability of a substance to act in a stimulatory capacity in small doses and to inhibit when given in larger amounts is, however, well recognized, eg, acetylcholine and nicotine. In the case of gastrin, this dual action has been thought of little importance in the physiologic mechanisms responsible for controlling its release and activity in the normal state.

Most studies2,4-9 on gastrin

Uvnas, B.:  The Gastric Secretory Excitant From the Pyloric Mucosa , Ada Physiol Scand 6:97-107 ( (Nov) ) 1943.Article
Gillespie, I.E., and Grossman, M.I.:  Inhibition of Gastric Secretion by Extracts Containing Gastrin , Gastroenterology 44: 301-310 ( (March) ) 1963.
Gregory, R.A., and Tracy, H.J.:  The Constitution and Properties of Two Gastrins Extracted From Hog Antral Mucosa , Gut 5:103-117 ( (April) ) 1964.Article
Gillespie, I.E.: " Inhibition of Acid Secretion by Gastrin Extracts ," in Grossman, M.I. (ed.): Gastrin , Berkeley, Calif: University of California Press, 1966, pp 139-169.
Konturek, S., and Grossman, M.I.:  Effect of Large Dose of Gastrin I on Pepsin Secretion , Proc Soc Exp Biol 119:443-444 ( (June) ) 1965.Article
Emas, S., and Grossman, M.I.:  Differences in Responses Between Dogs and Cats to Large Doses of Gastrin on Gastric Secretion , Gut 8:267-275 ( (June) ) 1967.Article
Emas, S., and Grossman, M.I.:  Comparison of Gastric Secretion in Conscious Dogs and Cats , Gastroenterology 52:29-34 ( (Jan) ) 1967.
Barabas, A.P., et al:  The Effect of Vagotomy on Gastrin-Stimulated Gastric-Acid Secretion in Man , Lancet 1:118-119 ( (Jan 15) ) 1966.Article
Makhlouf, G.M.; McManus, J.P.A.; and Card, W.I.: " Action of Gastrin II on Gastric Secretion in Man ," in Grossman, M.I. (ed.): Gastrin , Berkeley, Calif: University of California Press, 1966, pp 139-169.
Grossman, M.I., et al:  The Effect of Nausea on Gastric Secretion and a Study of the Mechanism Concerned , Gastroenterology 4:347-351 ( (April) ) 1945.
Passaro, E.P., and Goodman, G.:  Effects of Endogenous Gastrin on Acid Response to Histamine and Gastrin , Surg Forum 16:313, 1965.
Quintana, R.B.; De la Rosa, C.; and Dragstedt, L.R.:  The Effect of Endogenous Gastrin on Histamine Induced Gastric Secretion , Amer J Dig Dis 10:745-750 ( (Sept) ) 1965.Article
Barrett, A.M.; Raventos, J.; and Siddall, R.A.:  Influence of Some Anesthetics on Pharmacologically Stimulated Gastric Secretion in the Rat , Brit J Pharmacol 28:51-63 ( (Oct) ) 1966.