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Article
July 1969

Gastric Secretion and Chronic Hyperparathyroidism

Author Affiliations

Galveston, Tex
From the departments of medicine and surgery, University of Texas Medical Branch, Galveston, Tex.

Arch Surg. 1969;99(1):9-14. doi:10.1001/archsurg.1969.01340130011003
Abstract

Severe gastrointestinal symptoms arising in association with hyperparathyroidism are well known, but the pathophysiological characteristics of the symptoms are confusing. In some patients, these symptoms result from renal failure; in others, from acute or calcific pancreatitis, and in patients with acute hyperparathyroidism, inflammation and calcifications of the gastric mucosa occur. Furthermore, patients with hyperparathyroidism suffer from peptic ulcer, but the literature on the incidence of peptic ulcer in patients with this disorder is conflicting. Part of the confusion arises from the material available, the lack of reliable statistics on the frequency of ulcer disease in the general population, and the limitations imposed by diagnostic techniques.

Rogers1 who is generally cited as the first to report the concurrence of peptic ulcer and hyperparathyroidism, reported three such patients. Death resulted from uncontrolled hyperparathyroidism, but in two of the three patients the ulcers were healed at postmortem examination. Rogers' main concern was

References
1.
Rogers, H.M.:  Parathyroid Adenoma and Hypertrophy of the Parathyroid Glands , JAMA 130:22-28 ( (Jan 5) ) 1946.Article
2.
Ward, J.T.; Adesola, A.O.; and Welbourn, R.B.:  The Parathyroids, Calcium, and Gastric Secretion in Man and the Dog , Gut 5:173-183 ( (April) ) 1964.Article
3.
Murphy, D.L., et al:  Hypercalcemia and Gastric Secretion in Man , J Appl Physiol 21:1607-1610 ( (Sept) ) 1966.
4.
Barreras, R.F., and Donaldson, R.M., Jr.:  Effects of Induced Hypercalcemia on Human Gastric Secretion , Gastroenterology 52:670-675 ( (April) ) 1967.
5.
Barreras, R.F., and Donaldson, R.M., Jr.:  Role of Calcium in Gastric Hypersecretion, Parathyroid Adenoma and Peptic Ulcer , New Eng J Med 276:1122-1224 ( (May 18) ) 1967.Article
6.
Ostrow, J.D.; Blanshard, G.; and Gray, S.J.:  Peptic Ulcer in Primary Hyperparathyroidism , Amer J Med 29:769-779 ( (Nov) ) 1960.Article
7.
Donegan, W.L., and Spiro, H.M.:  Parathyroids and Gastric Secretion , Gastroenterology 38:750-761 ( (May) ) 1960.
8.
Kirsmer, J.B., in discussion, Donegan, W.L., and Spiro, H.M.:  Parathyroid and Gastric Secretion , Gastroenterology 38:750-761 ( (May) ) 1960.
9.
Ekeles, A.:  Parathyroid Tumour With Hyperparathyroidism and Coexistent Gastric and Duodenal Ulceration , Lancet 1:770-772 ( (April 18) ) 1953.Article
10.
Hellstrom, J.:  Hyperparathyroidism and Gastroduodenal Ulcer , Acta Chir Scand 116 ( (pt 3) ):207-221, 1959.
11.
Levin, E., et al:  The Variability and Periodicity of the Nocturnal Gastric Secretion in Normal Individuals , Gastroenterology 10:939-951 ( (June) ) 1948.
12.
Seigel, S.: Nonparametric Statistics for the Behavioral Sciences , New York: McGraw-Hill Book Co., 1956.
13.
Babkin, B.P.; Komarov, O.; and Komarov, S.A.:  The Effect of Activated Ergosterol and of Parathyroid Hormone on Gastric Secretion in the Dog , Endocrinology 26:703-715 ( (April) ) 1940.Article
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