[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address 54.211.41.181. Please contact the publisher to request reinstatement.
Sign In
Individual Sign In
Create an Account
Institutional Sign In
OpenAthens Shibboleth
[Skip to Content Landing]
Article
July 1969

The Effect of Acute Anemia and Iron Deficiency Anemia on Wound Healing

Author Affiliations

Palo Alto, Calif
From the Department of Surgery, Stanford Medical School, Palo Alto, Calif.

Arch Surg. 1969;99(1):113-116. doi:10.1001/archsurg.1969.01340130115023
Abstract

The "clinical impression" of many surgeons is that wounds heal better if the hematocrit is maintained at a normal level. However, a normal level for wound healing, below which healing is impaired, has not been defined. During a year of postoperative care of servicemen in Vietnam, my colleagues and I arbitrarily set the transition level at a hematocrit of 30% and transfused only if the hematocrit was below that level. We were motivated by the knowledge that healthy adults with normal iron stores could raise their hemoglobin 0.25 gm/100 cc/day1 and by the very real dangers of unnecessary transfusions, ie, hepatitis, incompatibility reaction, and the added load to the kidneys of clearing the breakdown products of old blood. With the known increase of the relative viscosity of blood with an increase in hematocrit,2 it was considered possible that small vessel perfusion was actually improved by limiting transfusion. We

References
1.
Coleman, D.H.; Stevens, A.R.; and Finch, C.A.:  The Treatment of Iron Deficiency Anemia , Blood 10:567-581 ( (June) ) 1955.
2.
Burton, A.C.: Physiology and Biophysics of the Circulation , Chicago: Year Book Medical Publisher, Inc., 1965.
3.
 Iron Deficiency in the United States, Committee on Iron Deficiency , JAMA 203:407-412 ( (Feb 5) ) 1968.Article
4.
McCall, M.G., et al:  The Experimental Production of Iron Deficiency in Growing Rats , Brit J Nutr 16:297-304, 1962.Article
5.
Trueblood, H.W., et al: Wound Healing in the Colon-Comparison of Inverted and Everted Closures, Surgery, to be published.
6.
Jacobson, M.J., and VanProhaska, J.:  The Healings of Wounds in Iron Deficiency , Surgery 57:254-258 ( (Feb) ) 1965.
7.
Bains, J.W.; Crawford, P.T.; and Ketcham, A.S.:  Effect of Chronic Anemia on Wound Tensile Strength , Ann Surg 164:243-246 ( (Aug) ) 1966.Article
8.
Sandberg, N., and Zederfeldt, B.:  Influence of Acute Hemorrhage on Wound Healing in the Rabbit , Acta Chir Scand 118:367-371 ( (April) ) 1960.
9.
Sandblom, P.:  The Tensile Strength of Healing Wounds , Acta Chir Scand , (suppl 89) , pp 5-108, 1944.
10.
Jurkiewicz, M.J., and Garrett, L.P.:  Studies on the Influence of Anemia on Wound Healing , Amer J Surg 30:23-25 ( (Jan) ) 1964.
11.
Besser, E.L., and Ehienhaft, J.L.:  Wound Healing in Acute Anemia , Surgery 14:239-245 ( (Aug) ) 1943.
12.
Ruch, T.C., and Fulton, T.F.: Medical Physiology and Biophysics , Philadelphia: W. B. Saunders Co., 1960.
13.
Beutler, E.: " Tissue Effect of Iron Deficiency " in Gross, F (ed.): Iron Metabolism , Berlin: Springer-Verlag, 1964.
14.
Kivirikko, K.I., and Prockop, D.J.:  Enzymatic Hydroxylation of Proline and Lysine in Protocollagen , Proc Nat Acad Sci 57:782-789 ( (March) ) 1967.Article
15.
Harris, J.W.: The Red Cell , Cambridge, Mass: Harvard Univ. Press, 1963.
×