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August 1969

An Evaluation of Bile Diversion on Induced Hypercholesterolemia

Author Affiliations

From the Department of Surgery, Creighton University School of Medicine and the Surgical Research Laboratories, Creighton Memorial St. Joseph's Hospital, Omaha.

Arch Surg. 1969;99(2):245-248. doi:10.1001/archsurg.1969.01340140117017

This presentation will attempt to shed some light on hypercholesterolemia, the mechanism of its development, and its prevention by relatively simple surgical procedures aimed at changing the body's basic physiological responses. These investigations assume clinical importance in light of the fact that hypercholesterolemia is considered an important factor in atherosclerosis, the latter being the number-one cause of death in the United States today. The following is a report of our continued experience with biliary diversion procedures on induced hypercholesterolemia in dogs, and a revaluation of the importance of the distal ileum in the bile salt enterohepatic circulation.

Materials and Methods  Hypercholesterolemia was induced in 40 adult, mongrel dogs by a modification of the procedure described by Scott and his colleagues.1 This consisted of a standard beef canned dog food mixed with 10 gm of cholesterol, 0.25 gm of thiouracil, and 40 gm of cottonseed oil. Since we employed a

Scott, H.W., Jr., et al:  Prevention of Experimental Atherosclerosis by Ileal Bypass: Twenty Per Cent Cholesterol Diet and 1-131 Induced Hypothyroidism in Dogs , Ann Surg 163:795-807 ( (May) ) 1966.Article
Keig, H.E., et al:  The Effect of Bile Diversion on Induced Hypercholesterolemia , Arch Surg 96:613-618 ( (April) ) 1968.Article
Whipple, G.H., and Smith, H.P.:  Bile Salt Metabolism: IV. How Much Bile Salt Circulates in the Body? , J Biol Chem 80:697-707 ( (Dec) ) 1928.
Weiner, I.M., and Lack, L.:  Absorption of Bile Salts From the Small Intestine in Vivo , Amer J Physiol 202:155-157 ( (Jan) ) 1962.
Heaton, K.W., et al:  Enterohepatic Circulation of C14: Labeled Bile Salts in Disorders of the Distal Small Bowel , Gastroenterology 55:5-16 ( (July) ) 1968.
DePalma, R.G., et al:  Regression and Prevention of Experimental Atherosclerosis: Effects of Diet and Bile Diversion in the Dog , Surgical Forum , Atlantic City American College of Surgeons 19:308-310 ( (Oct) ) 1968.