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Article
September 1969

The Fate of Intracerebral Adrenal Grafts in the Dog

Author Affiliations

Philadelphia
From the Department of Surgery, Hahnemann Medical College, Philadelphia. Dr. Dixit is now at Woodstock General Hospital, Woodstock, Ontario.

Arch Surg. 1969;99(3):352-355. doi:10.1001/archsurg.1969.01340150060011
Abstract

The first attempt to transplant the adrenal gland was made by Canalis in 1887.1 Now, 80 years later, a permanently successful adrenal autograft or allograft has yet to be documented. A large number of recorded experiments involving transplantation of various types of tissue to the brain seems to suggest that such transplants might enjoy prolonged survival without undergoing immunological rejection. Indeed, the brain is usually cited, along with the anterior chamber of the eye, as a classic example of an "immunologically privileged" site.2 This concept led us to consider whether intracerebral transplantation of adrenal tissue might prove to be a practical method for treating adrenal insufficiency. Silent areas of the brain would be appropriate sites for implantation with minimal risk of adverse neurological sequelae. The purpose of this article is to report our experience with intracerebral implantation of adrenal autografts and allografts in dogs. We conclude that such

References
1.
Canalis, P.:  Contribution a l'Etude du Développement et de la Pathologie des Capsules Surrenales , Int Monatschr fur Anat Physiol 4:312-334, 1887.
2.
Billingham, R.E., and Silvers, W.K.:  "Studies on Cheek Pouch Skin Homografts in the Syrian Hamster,"  in Wolstenholme, G.E.W., and Camerson, M.P. (eds.): Ciba Foundation Symposium on Transplantation , Boston: Little, Brown & Co., 1962, pp 90-117.
3.
Medawar, P.B.:  Immunity to Homologous Grafted Skin: III. The Fate of Skin Homografts Transplanted to the Brain, to Subcutaneous Tissue, and to the Anterior Chamber of the Eye , Brit J Exp Path 29:58-69 ( (Feb) ) 1948.
4.
Ebeling, F.:  Experimentelle Gehirntumoren bei Maeusen , Z Krebsforsch 14:151-156, 1914.Article
5.
Wilson, D.B., and Billingham, R.E.:  Lymphocytes and Transplantation Immunity , Advances Immun 7:189-273, 1967.
6.
Block, M.A.; Tworek, E.J.; and Miller, J.M.:  Parathyroid Homografts in Brain Tissue , Arch Surg 92:778-784, 1966.Article
7.
Lance, E.M.:  A Functional and Morphological Study of Intracranial Parathyroid Allografts in the Dog , Transplantation 5:1471-1483 ( (Nov) ) 1967.Article
8.
Lance, E.M.:  A Functional and Morphological Study of Intracranial Thyroid Allografts in the Dog , Surg Gynec Obstet 125:529-539, 1967.
9.
Siebert, W.J.:  Auto and Homoiotransplantation of Thyroid Gland into the Brain of Guinea Pigs , Proc Soc Exp Biol Med 26:236-237 (Dec) ) 1928.Article
10.
Pomerat, C.M.; Breckinridge, C.G.; and Gordon, L.:  Homplastic Adrenal Grafts to the Cerebral Cortex of the Rat , Endocrinology 34:60-68 ( (Jan) ) 1944.Article
11.
Castiglioni, G., et al:  Comparative Evaluation of Kidney and Brain as the Site of Transplantation of Adrenals , Chir Pat Sper 4:431-444 ( (May) ) 1956.
12.
Shirai, Y.:  On the Transplantation of the Rat Sarcoma in Adult Heterogeneous Animals , Japan Med World 1:14-15 (June 20, No. (2) ) 1921.
13.
Murphy, J.B.:  The Lymphocyte in Resistance to Tissue Grafting, Malignant Disease and Tuberculous Infection , Monogr Rockefeller Inst 21:1-68 ( (Sept 20) ) 1926.
14.
Tansley, K.:  The Development of the Rat Eye in Graft , J Exp Biol 22:221-224 ( (May) ) 1946.
15.
Scheinberg, L.C.; Edelman, F.L.; and Levy, W.A.:  Is the Brain "An Immunologically Privileged Site"? , Arch Neurol 11:248-264 ( (Sept) ) 1964.Article
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