[Skip to Content]
Sign In
Individual Sign In
Create an Account
Institutional Sign In
OpenAthens Shibboleth
[Skip to Content Landing]
January 1970

Response of Renal Allografts to Erythropoietic StimuliIn the Presence of Immunosuppression

Author Affiliations

From the departments of urology and experimental surgery, Roswell Park Memorial Institute, and Regional Kidney Center, New York State Kidney Institute, New York State Department of Health, and the School of Medicine, State University of New York, Buffalo.

Arch Surg. 1970;100(1):20-23. doi:10.1001/archsurg.1970.01340190022007

Erythropoietin (ESF) is a hormone of renal origin active in the regulation of red cell production.1 Various factors or stimuli are known to result in ESF release. These include bleeding,2 hypoxic hypoxia exposure,3 exogenous androgen administration,4 or cobalt chloride treatment.5 Autotransplanted canine kidneys can respond to various erythropoietic stimuli as can normal intact kidneys.6

The present experiments were conducted to test further the response of animals with renal allografts, with and without various forms of immunosuppression to various erythropoietic stimuli.

Materials and Methods  Adult male and female mongrel dogs, in healthy condition, underwent bilateral nephrectomy and received a kidney from an unrelated donor. Postoperatively, animals with functioning grafts were either untreated or given yeast respiratory extract (PCO),7 50 mg/kg every other day; azathioprine (Imuran), 5 mg/kg daily, or azathioprine and PCO in similar but combined fashion. Routine biochemical and hematological preoperative and postoperative

Gordon, A.S.:  Hemopoietine , Physiol Rev 39:1-40 ( (Jan) ) 1959.
Mirand, E.A., et al:  Erythropoietin Response to Repeated Hemorrhage in Renal Autotransplanted Nephrectomized, or Intact Dogs , Life Sci 7:689-695 ( (July) ) 1968.Article
Fisher, J.W., et al:  Effects of Cobalt on Activity of Sheep Erythropoietin in Rat Kidney Homogenates , Proc Soc Exp Biol Med 122:1015-1018 ( (Aug) -Sept) 1966.Article
Mirand, E.A., et al:  Effects of Testosterone on Renal Hemodynamics and Erythropoietin Release in Dogs , Invest Urol 4:203-207 ( (Nov) ) 1966.
Fisher, J.W., and Langston, J.W.:  The Influence of Hypoxemia and Cobalt on Erythropoietin Production in the Isolated Perfused Dog Kidney , Blood 29:114-125 ( (Jan) ) 1967.
Murphy, G.P., et al:  Erythropoietin Activity in Autotransplanted Canine Kidneys , Arch Surg 99:660-663 ( (Nov) ) 1969.Article
Murphy, G.P., et al:  The Effect of PCO (Yeast Respiratory Stimulator) on Imuran-treated and Untreated Dog Renal Allografts , Surg Forum 20:299-301 ( (Oct) ) 1969.
Mirand, E.A.; Prentice, T.C.; and Slaunwhite, W.R.:  Current Studies on the Role of Erythropoietin on Erythropoiesis , Ann NY Acad Sci 77:677-702 ( (Jan) ) 1959.Article
Mirand, E.A., and Murphy, G.P.:  Erythropoietin Alterations in Patients With Uremia, Renal Allografts, or Without Kidneys , JAMA 209:392-398 ( (July) ) 1969.Article
Mirand, E.A.:  Extrarenal and Renal Control of Erythropoietin Production , Ann NY Acad Sci 149:94-106 ( (March) ) 1968.Article