[Skip to Content]
Sign In
Individual Sign In
Create an Account
Institutional Sign In
OpenAthens Shibboleth
[Skip to Content Landing]
November 1970

Historic and Current Intra-arterial Chemotherapy

Author Affiliations

Long Beach, Calif
From the City of Hope Medical Center, Department of General and Oncologic Surgery, Duarte, Calif.

Arch Surg. 1970;101(5):570-577. doi:10.1001/archsurg.1970.01340290026006

Phases of historical development of intra-arterial chemotherapy at this institution have been outlined. Our experience, exclusive of previously reported series, during the past 12 years in treating 130 patients with advanced cancer by this modality has been described. The overall objective response rate was 35%. Although 40% of the epidermoid carcinoma of the head and neck cases responded favorably, the duration of response was short lived. Best results were seen in the liver series where 43% of the cases experienced a response lasting an average of five months. Patients with epidermoid carcinoma of the pelvis at best experienced symptomatic relief in the majority of cases but with little objective response. Although much improvement in technical placement and management of indwelling catheters with resulting reduction of complications has been experienced, initial enthusiasm has declined in recent years.

Breedis C, Young G:  Blood supply of neoplasms in liver . Fed Proc 8:351, 1949.
Seligman AM, Ulfohn A, Gaby SD, et al:  Enzyme alterable alkylating agents: A new approach to regional chemotherapy in intra-arterial infusion of new short-lived alkylating agents . Ann Surg 156:429-441, 1962.Article
Goodman LE, Ulfohn A, Kramer SP, et al:  Enzyme alterable alkylating agents: VIII. Clinical trials with intra-arterial infusion of an alkylating agent with a half-life of 0.2 second . Ann Surg 162: 663-689, 1965.Article
Bierman HR, Miller ER, Byron RL Jr, et al:  Intra-arterial catheterization in man . Bull Univ Calif Med Center 1:84-88, 1949.
Byron RL Jr, Singh BP, Bierman HR, et al:  Intra-aortic nitrogen mustard therapy in advanced pelvic malignancies . Surgery 45:634-641, 1959.
Byron RL Jr, Perez FM, Yonemoto RH, et al:  Left brachial arterial catheterization for chemotherapy in advanced intra-abdominal malignant neoplasms . Surg Gynec Obstet 112:689-696, 1961.
Byron RL Jr, Yonemoto RH, Hallauer WC, et al:  Radical mastectomy with arterial regional chemotherapy . Surgery 49:681-686, 1961.
Byron RL Jr, Cronemiller PD, Bierman HR, et al:  Interscapulothoracic amputation and sacroiliac disarticulation with adjunctive arterial chemotherapy . Surg Gynec Obstet 111:457-463, 1960.
Yonemoto RH, Byron RL Jr, Jacobs ML:  Combined irradiation, intra-arterial chemotherapy and surgery for the treatment of sarcomas of the extremities . Surgery 61:355-360, 1967.
Watkins E Jr, Sullivan RD:  Cancer chemotherapy by prolonged arterial infusion . Surg Gynec Obstet 118:3-19, 1964.
Papac R, Lefkowitz E, Bertino JR:  Methotrexate (NSC-740) in squamous cell carcinoma of the head and neck: II. Intermittent intravenous therapy . Cancer Chemother Rep 51:69-72, 1967.
Kramer S:  Combined chemotherapy and radiation therapy in the management of regional cancer , in Brodsky J, Kahn SB (eds): Cancer Chemotherapy . New York and London, Grune & Stratton Inc, 1967, pp 319-330.
Leone LA, Albala MM, Rege VB:  Treatment of carcinoma of the head and neck with intravenous methotrexate . Cancer 21:828-837, 1968.Article
Steinfeld JL, Solomon J:  Treatment of gastric carcinoma , in Kinosita R, Nagayo T, Tanaka T (eds): Epidemiological, Experimental, and Clinical Studies on Gastric Cancer . Tokyo, Maruzen Co Ltd, 1968, pp 261-267.