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August 1971

Hemodynamic Effects of Vasodilatation in "Critical" Arterial Stenosis

Author Affiliations

From the Department of Surgery, State University of New York at Buffalo and the Surgical Research Laboratories, Edward J. Meyer Memorial Hospital, Buffalo.

Arch Surg. 1971;103(2):277-282. doi:10.1001/archsurg.1971.01350080193030

The effect of two intra-arterially injected vasodilating agents on the oxygen uptake of tissue and on blood flow through a critical stenosis has been investigated in the dog. Blood flow increase always occurred through the stenotic segment, but this change was small. Concomitant with this small flow increase the oxygen consumption of the tissue distal to the stenosis was found to be significantly decreased by the vasodilator infusion. This decreased oxygen consumption was manifested by marked narrowing of the arteriovenous oxyhemoglobin difference, suggesting that the agents infused opened arteriovenous shunts.

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