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Article
September 1971

The Binding of Aldosterone to Echerichia coli Endotoxin

Author Affiliations

Philadelphia
From the departments of surgery and biological chemistry, Hahnemann Medical College, Philadelphia.

Arch Surg. 1971;103(3):402-405. doi:10.1001/archsurg.1971.01350090084018
Abstract

Aldosterone has been reported to lower the fatality rate in laboratory animals administered a lethal dose of endotoxin. It has been suggested that this beneficial effect of aldosterone may be due to a physical combination of the steroid with endotoxin, which would result in a decreased toxicity of the endotoxin. To test this hypothesis, the binding capacity of Escherichia coli endotoxin for aldosterone was measured by Sephadex filtration chromatography, and by comparing the rate of dialysis of aldosterone in the presence and absence of endotoxin. Within the limitations of both of the methods used, the results of this investigation indicate that E coli endotoxin does not have a strong affinity for d-aldosterone in purified systems.

References
1.
Bein HJ, Jacques R:  The antitoxic effect of aldosterone . Experientia 16:24-26, 1960.Article
2.
Halberg F, Spink W, Bittner J:  Protection by aldosterone and 11, 17 oxycorticoids against effects of Brucella somatic antigen in adrenalectomized mice . Endocrinology 59:380-383, 1956.Article
3.
Spink W, Vick J:  Canine endotoxin shock, reversal with aldosterone and angiotensin II . Proc Soc Exp Biol Med 109:521-522, 1962.Article
4.
Spink W, Vick J, Finstad J:  Influence of aldosterone and angiotensin II on endotoxic shock . Proc Soc Exp Biol Med 112:795-799, 1963.Article
5.
Vaughn D, Bersentes T, Kirschbaum J, et al:  Homeostatic role of the renal adrenal axis in bacteremic shock . Amer J Obstet Gynec 99:208-215, 1967.
6.
Vaughn D, Kirschbaum J, Bersentes T, et al:  Effects of corticosteroid hormones on regional circulation in endotoxin shock . Proc Soc Exp Biol Med 124:760-764, 1967.Article
7.
Hayasaka H, Howard JM:  Mechanism of action of D-aldosterone on cats in endotoxic shock . Surgery 54:761-763, 1963.
8.
Hayasaka H, O'Malley J, Howard JM:  Antitoxic effect of aldosterone on cats in endotoxic shock . Arch Surg 87:861-865, 1963.Article
9.
Kostrubiak W, Hayasaka H, Howard JM:  The protective effects of aldosterone against the lethality of experimental endotoxemia and exotoxemia , in Shock and Hypotension, 12th Hahnemann Symposium . LC Mills (ed), New York, Grune & Stratton Inc, 1965.
10.
Braude AI, Carey FJ, Zalesky M:  Studies with radioactive endotoxin II: Correlation of physiologic effects with distribution of radioactivity in rabbits injected with lethal doses of E coli endotoxin labelled with radioactive sodium chromate . J Clin Invest 34:858-866, 1953.Article
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