In eight well-nourished dogs hemorrhagic pancreatitis could be induced in all by injection of autologous bile and trypsin into the main pancreatic duct, whereas in eight experimentally undernourished dogs, it was possible in only two. In other dogs in both groups the concentrations of proelastase and trypsinogen of the pancreas were estimated and found to be normal in the well-fed, diminished in the malnourished. It is concluded that the preoperative nutritional status of the dog must be taken into account in planning experiments involving the pathogenesis and the evaluation of new therapeutic agents in acute pancreatitis.
Goodhead B. Importance of Nutrition in the Pathogenesis of Experimental Pancreatitis in the Dog. Arch Surg. 1971;103(6):724-727. doi:10.1001/archsurg.1971.01350120088016