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December 1971

An Autonomously Functioning Thyroid Nodule, Cancer, and Prior RadiationCase Report and Hypothesis

Author Affiliations

Southfield, Mich
From Northfield Thyroid Laboratory, Southfield, Mich.

Arch Surg. 1971;103(6):759-761. doi:10.1001/archsurg.1971.01350120123024

The frequency with which the coexistence of thyroid cancer and autonomously functioning thyroid nodules (AFTN) is reported (both uncommon conditions) suggests that their association may not be entirely coincidental. Radiation therapy may predispose to the development of both benign and malignant thyroid nodules. Four of our 98 patients with AFTN gave histories of prior radiation therapy; one had coexistent thyroid cancer (the first described patient with AFTN and cancer after radiation therapy). It is suggested that a history of prior radiation therapy be diligently sought for all patients with AFTN, and, when obtained, further management planned with due regard for the possibility of coexistent cancer.

Miller JM, Hamburger JI:  The thyroid scintigram: I. The hot nodule . Radiology 84:66-74, 1965.Article
Hamburger JI, Werch SC, Kadian G, et al:  The spectrum of autonomous function in thyroid nodules . Michigan Med 67:44-66, 1968.
Miller JM, Block MA:  Functional autonomy in multinodular goiter . JAMA 214:535-539, 1970.Article
Kendall LW, Condon RE:  Prediction of malignancy in solitary thyroid nodules . Lancet 1:1071-1073, 1969.Article
Grant HTH, Canter JW, Lenhardt HF:  The enigmatic thyroid nodule . Ann Surg 158:205-210, 1963.Article
Attie JN:  The use of radioactive iodine in the evaluation of thyroid nodules . Surgery 47:611-614, 1960.
Dische S:  The radioisotope scan applied to the detection of carcinoma in thyroid swellings . Cancer 17:473-479, 1964.Article
Molnar GD, Childs DS Jr, Woolner LB:  Histologic evidence of malignancy in a thyroid gland bearing a "hot" nodule . J Clin Endocr 18:1132-1134, 1958.Article
Meadows PM:  Scintillation scanning in the management of the clinically single thyroid nodule . JAMA 177:229-234, 1961.Article
Becker FO, Economou PG, Schwartz TB:  The occurrence of carcinoma in "hot" thyroid nodules . Ann Intern Med 58:877-882, 1963.Article
Wilson SM, Platz C, Block GM:  Thyroid carcinoma after irradiation . Arch Surg 100:330-337, 1970.Article
McCormack KR, Sheline GE:  Long-term studies of solitary autonomous thyroid nodules . J Nucl Med 8:701-708, 1967.