[Skip to Content]
Sign In
Individual Sign In
Create an Account
Institutional Sign In
OpenAthens Shibboleth
[Skip to Content Landing]
February 1972

Inhibition of Experimental Mammary CarcinomaAutologous Intrasplenic Ovarian Transplant

Author Affiliations

From the Department of Surgery and the Fels Research Institute of Temple University Health Sciences Center, Philadelphia.

Arch Surg. 1972;104(2):206-208. doi:10.1001/archsurg.1972.04180020086017

Intrasplenic ovarian autotransplantation is associated with significant inhibition of 7,12-dimethylbenz (a) anthracene-produced breast carcinoma in the rat. The mechanism of this inhibition may be related to the position of the transplanted ovary within the portal venous system, allowing initial drainage of ovarian venous efflux through the liver. Hepatic alteration of ovarian hormones could result in changes in hormone concentration within the mammary gland, and this may represent the mechanism of inhibition of tumorigenesis. End-to-side portacaval shunt done simultaneously with intrasplenic ovarian transplantation is also associated with significant inhibition of experimental breast carcinoma. The previously observed inhibition of experimental breast carcinoma by end-to-side portacaval shunt alone has been reconfirmed.

Reichle FA, Gruenstein M, Meranze DR, et al:  The effect of portacaval shunt on 7,12-dimethylbenz(a)anthracene-produced mammary carcinoma in the rat . J Surg Res 9:559-565, 1969.Article
Huggins D, Briziarelli G, Sutton H Jr.  Rapid induction of mammary carcinoma in the rat and the influence of hormones on the tumors . J Exp Med 109:25-42, 1959.Article
Kim U, Furth J:  Relation of mammary tumors to mammotropes: II. Hormone responsiveness of 3-methylcholanthrene-induced mammary carcinoma . Proc Soc Exp Biol Med 103:643-645, 1960.Article
Reichle FA, Brigham MP, Tyson RR, et al:  Histidine metabolism after portacaval shunt in the rat . J Surg Res 8:320-325, 1968.Article
Turner CD: General Endocrinology , ed 4. Philadelphia, WB Saunders Co, 1966, pp 470-471.
Reichle FA, Brigham MP, Tyson RR, et al:  Histidine metabolism after portacaval shunt in the rat . Surg Forum 18:338-340, 1967.
Reichle FA, Brigham MP, Tyson RR, et al:  Serine metabolism after portacaval shunt . Arch Surg 100:163-166, 1970.Article
Brown H, Yashruti S, Brown J, et al:  Urea cycle enzyme activity in dogs following portacaval shunt operations . Surg Forum 14:81-83, 1963.
Schimke RT:  Adaptive characteristics of urea cycle enzymes in the rat . J Biol Chem 327:459-468, 1962.
Richmond J, Girdwood RH:  Observations on aminoacid absorption . Clin Sci 22:301-314, 1962.
Young S, Cowan DM, Sutherland LE:  The histology of induced mammary tumors in rats . J Path Bact 85:331-340, 1963.Article
Geschickter CF:  Mammary carcinoma in the rat with metastasis induced by estrogen . Science 89:35-37, 1939.Article
Mackenzie I:  The production of mammary cancer in rats using oestrogens . Brit J Cancer 9:284-299, 1955.Article
Huggins C, Yang NC:  Induction and extinction of mammary cancer . Science 137:257-262, 1962.Article