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Article
March 1972

Improved Technology and Enhanced Accomplishment of Gastric FreezingAn Experimental Study

Author Affiliations

Minneapolis
From the Department of Surgery, Health Sciences Center, University of Minnesota, Minneapolis.

Arch Surg. 1972;104(3):314-318. doi:10.1001/archsurg.1972.04180030062014
Abstract

With the aid of bioengineering expertise, a technological process has been evolved that makes it possible to achieve a fairly uniform gastric freeze of the intact canine stomach, with only small disparities in the temperature of thermocouples dispersed over the surface of the intragastric balloon. An ice crystal slush in 30% glycerol has a large cooling capacity and resists warming far more effectively than does the 80% alcohol coolant used in prior gastric freeze efforts. Liquid nitrogen is employed to cool the iceslush glycerol mixture, which is circulated at a minimum flow rate of 6 liters/min. Guide lines of a safe freeze have been defined, which include control of intraluminal balloon pressure during the freeze, heparin sodium to preclude mucosal necrosis, and delimitation of the length and depth of the balloon surface thermocouple temperature depression during the freeze. Significant gastric secretory depression to graded doses of histamine diphosphate was consistently observed at all levels of histamine dosage up to 6 months after the freeze, with a gradual return to prefreeze levels at 12 months.

References
1.
Goodale RL Jr, Delaney JP, Engle JC, et al:  The duration of achlorhydria attending freezing of the isolated canine gastric pouch . J Surg Res 5:370-376, 1965.Article
2.
McFee AS, Stone NA, Goodale RL Jr, et al:  Prevention of stress induced ulceration in the rat by gastric freezing . JAMA 186:917-919, 1963.Article
3.
McIlrath DC, Hallenbeck GA, Allen HA, et al:  Gastric freezing: An experimental study . Gastroenterology 45:374-383, 1963.
4.
Marx FW, Kolig G:  Hemorrhagic necrosis following gastric freezing . Surg Gynec Obstet 119:1276-1284, 1964.
5.
Buchan R, Clark CG, Love RM:  Histological studies of the frozen stomach of the rat . Brit J Surg 52:230-233, 1965.Article
6.
Goodale RL Jr: Some Bioengineering Studies of Gastric Freezing, thesis. University of Minnesota, Minneapolis, 1967.
7.
Emas S, Grossman MI:  Effect of truncal vagotomy on acid and pepsin responses to histamine and gastrin in dogs . Amer J Physiol 212:1007-1012, 1967.
8.
Silbermann OH, Williams HTG, Pisesky W, et al:  Experimental production of peptic ulceration . Surg Forum 9:455-457, 1958.
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