[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address Please contact the publisher to request reinstatement.
Sign In
Individual Sign In
Create an Account
Institutional Sign In
OpenAthens Shibboleth
[Skip to Content Landing]
May 1972

Oxygen Consumption and Systemic Hemodynamics During Low Perfusion AcidosisEffect of Isoproterenol and Lactated Ringer's Solution

Author Affiliations

Loma Linda, Calif
From the Department of Surgery, Surgical Research Laboratory, Loma Linda (Calif) University School of Medicine.

Arch Surg. 1972;104(5):692-695. doi:10.1001/archsurg.1972.04180050066015

Isoproterenol hydrochloride and lactated Ringer's solution were employed in the treatment of low perfusion acidosis produced by acute blood volume reduction in 27 dogs. Their relative effectiveness was determined by measuring oxygen consumption, cardiac rate and output, and blood pressure. Neither isoproterenol nor lactated Ringer's solution produced significant improvement in either cardiac function or oxygen uptake. Significant improvement did, however, result when lactated Ringer's solution and isoproterenol were used in combination.

Collip JB:  Reversal of depressor action of small doses of adrenalin . Amer J Physiol 55:455-461, 1921.
Campbell GS, Houle DB, Crisp NW, et al:  Depressed response to intravenous sympathicomimetric agents in humans during acidosis . Dis Chest 33:18-22, 1958.Article
Guzman SV, DeLeon AC, West JW, et al:  Cardiac effects of isoproterenol, norepinephrine and epinephrine in complete A-V heart block during experimental acidosis and hyperkalemia . Circ Res 7:666-672, 1959.Article
Thrower DR, Darby TD, Aldinger EE:  Acid-base derangements and myocardial contractility . Arch Surg 82:56-65, 1961.Article
Silberschmid M, Smith LL, Staehelin HB, et al:  Isoproterenol and cardiac response to experimental lactic acidosis . Surgery 63:181-187, 1968.
DuBois EF: Basal Metabolism in Health and Disease , ed 3. Philadelphia, Lea & Febiger, 1936.
Rothe CF:  Oxygen deficit in hemorrhagic shock in dogs . Amer J Physiol 214:436-442, 1968.
Barker SB, Summerson WH:  Determination of lactic acid . J Biol Chem 138:535-554, 1941.
Clark WD, Morrow AG, Berry WB, et al:  Effects of heart rate on the maintenance of cardiac output and arterial pressure in hemorrhagic shock . Surg Forum 14:8-9, 1963.
Baue AE, Jones EF, Parkins WM:  The effect of beta adrenergic receptor stimulation on blood flow, oxygenative metabolism and survival in hemorrhagic shock . Ann Surg 197:403-413, 1968.Article
Grega GJ, Kinnard WJ:  Protective effects of nylidrin and isoproterenol against hemorrhagic shock . J Pharmacol Exp Ther 161:98-110, 1968.
MacConnell KL, Moran PC:  Pharmacologic basis for the use of adrenergic agonists and antagonists in cardiogenic shock and hypotension . Progr Cardiovasc Dis 10:55-63, 1967.Article
Euler US von:  Some factors affecting catecholamine uptake, storage, and release in adrenergic nerve granules . Circ Res 3 ( (suppl 20, 21) ):5-11, 1967.
Volle RL: International Encyclopedia of Pharmacology and Therapeutics . New York, Pergamon Press Inc, 1966, vol 1, Sec 12.