[Skip to Content]
Sign In
Individual Sign In
Create an Account
Institutional Sign In
OpenAthens Shibboleth
[Skip to Content Landing]
September 1972

Intravenous Prednisolone and Acetic Acid on the Antral Phase of Gastric Secretion

Author Affiliations

From the Department of Surgery, State University of New York, Buffalo; and the Edward J. Meyer Memorial Hospital, Buffalo.

Arch Surg. 1972;105(3):467-472. doi:10.1001/archsurg.1972.04180090072018

In dogs with Heidenhain pouches, the outputs of H+ elicited by endogenous gastrin were increased by administration of prednisolone intravenously; the outputs of Na+ were unchanged. An instillment of acetic acid reduced the outputs of H+ and increased the outputs of Na+, without provoking mucosal hemorrhage. When prednisolone was administered intravenously and acetic acid was administered topically, simultaneously, the outputs of H+ were higher than control values but lower than when prednisolone was given alone; the outputs of Na+ were higher than those noted after exposure of the pouches to acetic acid alone and hemorrhage occurred consistently. The results indicated that the degree of mucosal damage caused by acetic acid alone was increased by simultaneous administration of prednisolone. Nevertheless, the damaged mucosa still secreted increased outputs of H+ in response to the prednisolone.

Habif DV, Hare CC, Glaser GH:  Perforated duodenal ulcer associated with pituitary adrenocorticotropic hormone (ACTH) therapy . JAMA 144:996, 1950.Article
Smyth GA:  Activation of peptic ulcer during pituitary adrenocorticotropic hormone therapy: Report of three cases . JAMA 145:474-477, 1951.Article
Lubin RI, Misbach WD, Zanke EM, et al:  Acute perforation of. duodenal ulcer during ACTH and cortisone therapy . Gastroenterology 18:308-312, 1951.
Kern F Jr, Clark GM, Lukens JG:  Peptic ulceration occurring during therapy for rheumatoid arthritis . Gastroenterology 33:25-33, 1957.
Kammerer WH, Freiberger RH, Rivelis AL:  Peptic ulcer in rheumatoid patients on corticosteroid therapy: A clinical, experimental and radiological study . Arthritis Rheum 1:122-141, 1958.Article
Dubois EL, Bulgrin JG, Jacobson G:  The cortico-steroid induced peptic ulcer: A serial roentgenological survey of patients receiving high dosages . Amer J Gastroent 33:435-453, 1960.
Gray SJ, Ramsey CG:  Adrenal influence upon the stomach and the gastric responses to stress . Recent Progr Hormone Res 13:583-617, 1957.
Plainos TC, Phillippu AJ:  Effect of prednisone (Meticorten) on gastric secretion and urine and uropepsin excretion in the dog . Gastroenterology 35:183-189, 1958.
Forsham PH, Diraimonto V, Burns T, et al: Proceedings of the First International Conference on the Clinical and Metabolic Effects of Meticorten and Meticortelone . Kock GS (ed): Bloomfield, NJ, Schering Corp, 1955.
Carbone JV, Liebowitz D:  The effect of adrenal corticoids on gastric secretion and the suppression of corticoid-induced hypersecretion by anticholinergics . Metabolism 7:70-77, 1958.
Zubiran JM, Kark AE, Dragstedt LR:  Effect of ACTH on gastric secretion in experimental animals . Gastroenterology 21:276-279, 1952.
Zubiran JM, Kark AE, Montalbetti AJ, et al:  Peptic ulcer and the adrenal stress syndrome . Arch Surg 65:809-815, 1952.Article
Chaikof L, Janke WH, Pesaros PC, et al:  Effects of prednisone and corticotropin on gastric secretion . Arch Surg 83:32-41, 1961.Article
Clarke SD, Neill DW, Welbourn RB:  The effects of corticotropin and corticoids on secretion from denervated gastric pouch in dogs . Gut 1:36-43, 1960.Article
Ragins H, Dragstedt LR II, Landor JH, et al:  Duodenal ulcer and hypophysioadrenal stress mechanism . Surgery 40:886-893, 1956.
Beck IT, Fletcher HW, McKenna RD, et al:  Effect of small and massive doses of prednisone on gastric secretory activity . Gastroenterology 38:740-749, 1960.
Drye JC, Schoen AM:  Studies on the mechanisms of the activation of peptic ulcer after non-specific trauma: Effect of cortisone on gastric secretion . Ann Surg 147:738-748, 1958.Article
Wiederanders RE, Classen KL, Gobbel WG Jr:  The effect of cortisone and diet on the acid secretion of the Heidenhain pouch . Surg Forum 9:434-435, 1958.
Skoryna SC, Webster DR, Kahn DS:  A new method of production of experimental gastric ulcer: Effects of hormonal factors on healing . Gastroenterology 34:1-10, 1958.
Traut EF:  Gastric ulcer during steroid therapy in a patient with persistent achlorhydria: Effects of antirheumatic therapy: Case report . Ann Intern Med 49:1410-1411, 1958.Article
Flemstrom G, Frenning B, Obrink KJ:  The disappearance of acetic acid and acetate from the cat's stomach and its influence on the permeability for hydrochloric acid . Acta Physiol Scand 62:422-428, 1964.Article
Davenport HW:  Gastric mucosal injury by fatty and acetyl salicylic acids . Gastroenterology 46:245-253, 1964.
Davenport HW:  Damage to the gastric mucosa: Effects of salicylates and stimulation . Gastroenterology 49:189-196, 1965.
Davenport HW:  Potassium fluxes across the resting and stimulated gastric mucosa: Injury by salicylic and acetic acids . Gastroenterology 49:238-245, 1965.
Davenport HW:  Fluid produced by the gastric mucosa during damage by acetic and salicylic acid . Gastroenterology 50:487-499, 1966.
Davenport HW, Warner HA, Code CF:  Functional significance of gastric mucosa barrier to sodium . Gastroenterology 47:142-152, 1964.
Snedecor GW: Statistical Methods . Amos, Iowa, Iowa State University Press, 1962.
Aubrey DA, Burns GP:  Topically administered prednisolone and the antral phase of gastric secretion . Arch Surg 105:448-453, 1972.Article
Aubrey DA, Burns GP: The effect of acetic acid on the antral phase of gastric secretion after prolonged systemic administration of prednisolone. Amer J Surg, to be published.