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Article
April 1973

Mumps Virus and BCG Vaccine in Metastatic Melanoma

Author Affiliations

Columbus, Ohio
From the Department of Surgery, Ohio State University College of Medicine, Columbus.

Arch Surg. 1973;106(4):503-506. doi:10.1001/archsurg.1973.01350160117019
Abstract

Eight patients with metastatic melanoma were treated with surgical excision of the tumor, chemotherapy, BCG vaccine, and killed mumps virus injections. Five of these eight patients had additional clinical control of their malignant melanoma when killed mumps virus was added to the immunological stimulation sequence. The dramatic clinical benefit of immunologic stimulation with killed mumps virus in melanoma patients is believed to be transient.

References
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Morton DL, Wells SA Jr:  Immunobiology of neoplastic disease: Melanoma , in Sabiston DC Jr (ed): Textbook of Surgery , ed 10. Philadelphia, WB Saunders Co, 1972, pp 542-564.
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Morton DL, et al:  Immunological aspects of neoplasm: A rational basis for immunotherapy . Ann Intern Med 74:587-604, 1971.Article
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Bluming AZ, et al:  Immunologic effects of BCG in malignant melanoma: Two modes of administration compared . Ann Intern Med 76:405-411, 1972.Article
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Seigler HF, et al:  Nonspecific and specific immunotherapy in patients with melanoma . Surgery 72:162-174, 1972.
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Minton JP: The isolation of soluble human melanoma antigens and their immunologic testing. Read before the Association for Academic Surgery, New Orleans, 1972.
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