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September 1973

Metabolic Acidosis, Stress, and Gastric Lesions in the Rat

Author Affiliations

Washington, DC
From the Division of Surgery, Walter Reed Army Institute of Research, Walter Reed Army Medical Center, Washington, DC.

Arch Surg. 1973;107(3):456-459. doi:10.1001/archsurg.1973.01350210086022

Although gastric bleeding is a complication of renal failure, little is known about the causative factors. The possible mechanistic role of metabolic acidosis was studied in rats made acidotic by ingestion of 1.6% ammonium chloride. Since patients with renal failure may be in a stressed condition, the number of gastric lesions produced was studied in rats with and without seven hours of restraint stress. When arterial blood pH was reduced to 7.26, metabolic acidosis had no effect on the stomach. With a pH of 7.17, there was an increase in the number of gastric erosions in rats with restraint. Acidosis had no effect on gastric acid production or equilibration, on in vitro oxidative metabolism of gastric mucosa, or on gastric morphologic features in noneroded areas. These studies suggest that metabolic acidosis may account in part for gastric lesions associated with renal failure.

Balslov JT, Jorgensen HE:  A survey of 499 patients with acute anuric renal insufficiency . Am J Med 34:753-764, 1963.Article
Lucas CE, et al:  Natural history and surgical dilemma of "stress" gastric bleeding . Arch Surg 102:266-273, 1971.Article
Kleinknecht D, et al:  Uremic and nonuremic complications in acute renal failure: Evaluation of early and frequent dialysis on prognosis . Kidney Int 1:190-196, 1972.Article
Fischer RP, Stremple JF:  Stress ulcers in post-traumatic renal insufficiency in patients from Vietnam . Surg Gynecol Obstet 134:790-794, 1972.
Lordon RE, Burton J:  Post-traumatic renal failure in military personnel in Southeast Asia . Am J Med 53:137-147, 1972.Article
Elkington JR:  Renal acidosis . Am J Med 28:165-168, 1960.Article
Schwartz WB, Relman AS:  Acidosis in renal disease . N Engl J Med 256:1184-1186, 1957.Article
Freedman LR, Beeson PB:  Experimental pyelonephritis: VIII. The effect of acidifying agents on susceptibility to infection . Yale J Biol Med 33:318-331, 1961.
Rossi G, et al:  Technique nouvelle pour produire des ulceres gastriques chez le rat blanc: L'ulcere de contrainte . C R Soc Biol 150:2124-2126, 1956.
Brodie DA, Hanson HM:  A study of the factors involved in the production of gastric ulcers by the restraint technique . Gastroenterology 38:353-360, 1960.
Mullane JF, et al:  Experimental biliary obstruction and stress ulcer formation . J Surg Res 12:180-184, 1972.Article
Epstein RM, et al:  The effect of hypercapnia on estimated hepatic blood flow, circulating splanchnic blood volume, and hepatic sulfobromophthalein clearance during general anesthesia in man . J Clin Invest 49:592-598, 1961.Article
Tashkin DP, Goldstein PJ, Simmons DH:  Effect of acute respiratory acidosis on mesenteric circulation of dogs . Am J Physiol 217:1549-1558, 1969.
Ambrus JL, Ambrus CM, Harreson JWE:  Gastric acid secretion and gastric ulcer formation of rats and guinea pigs . Am J Physiol 173:95-99, 1953.
Skoryna SL, Webster DR:  A method of collection of pure gastric secretion in rats . Surg Forum 10:193-196, 1959.
Shay H, Sun DCH, Gruenstein M:  A quantitative method for measuring spontaneous gastric secretion in the rat . Gastroenterology 26:906-913, 1954.
Linder AE:  Electrolyte changes in rat stomachs following instillation of acid solutions . Am J Physiol 207:606-612, 1964.
Kety SS, et al:  The blood flow and oxygen consumption of the human brain in diabetic acidosis and coma . J Clin Invest 27:500-510, 1948.Article
Heyman A, Patterson JL, Jones RW, Jr:  Cerebral circulation and metabolism in uremia . Circulation 3:558-563, 1951.Article
Scheinberg P:  Effects of uremia on cerebral blood flow and metabolism . Neurology 4:101-105, 1954.Article
Goldstein E, Green GN, Seamans C:  The effect of acidosis on pulmonary bactericidal function . J Lab Clin Med 75:912-923, 1970.
Huber G, et al:  Experimental diabetes mellitus and pulmonary antibacterial host mechanisms . Clin Res 20:530, 1972.
Haperin ML, et al:  Factors that control the effect of pH on glycolysis in leukocytes . J Biol Chem 244:384-390, 1969.
Walker BG, et al:  Inhibition of insulin by acidosis . Lancet 2:964-965, 1963.Article
Welt LG, Sachs JR, McManus TJ:  An ion transport defect in erythrocytes from uremic patients . Trans Assoc Am Physicians 77:169-181, 1964.
Storer EH, et al:  Effect of the Exalto-Mann-Williamson procedure on gastric secretion . Arch Surg 64:192-199, 1952.Article
Byers FM, Jordan PH Jr, Maren TH:  Effects of acetazolamide and metabolic acidosis and alkalosis upon gastric acid secretion . Am J Physiol 202:429-436, 1962.
Bergofsky EH, et al:  The effects of acute alkalosis and acidosis on the pulmonary circulation . Ann NY Acad Sci 92:627-631, 1961.Article
Linde LM, Simmons DH, Lewis N:  Pulmonary hemodynamics in respiratory acidosis in dogs . Am J Physiol 205:1008-1013, 1963.
Shapiro BJ, Simmons DH, Linde LM:  Pulmonary hemodynamics during acute acid-base changes in the intact dog . Am J Physiol 210:1026-1032, 1966.
Betz E, Heuser D:  Cerebral cortical blood flow during changes of acid-base equilibrium of the brain . J Appi Physiol 23:726-733, 1967.
Brooker WH, Ansell JS, Brown EB Jr:  Effect of respiratory acidosis on renal blood flow . Surg Forum 10:869-871, 1959.
Bersentes TJ, Simmons DH:  Effects of acute acidosis on renal hemodynamics . Am J Physiol 212:633-640, 1967.
Relman AS:  Metabolic consequences of acid-base disorders . Kidney Int 1:347-359, 1972.Article
Canzonelli A, et al:  The effect of pH changes in the in vitro O2 consumption of tissues . Am J Physiol 127:290-295, 1939.
Tobin RB, Mehlman MA:  pH effects on 0, consumption and on lactate and pyruvate production by liver slices . Am J Physiol 221:1151-1155, 1971.