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May 1974

Early Posttransplant Renal Nonfunction

Author Affiliations

Torrance, Calif
From the Greater Los Angeles Mobile Kidney Preservation Unit, UCLA-Harbor General Hospital, Torrance, Calif (Dr. Moore and Mr. English), and departments of surgery, UCLA (Dr. Moore) and the University of Southern California, Los Angeles (Dr. Berne).

Arch Surg. 1974;108(5):685-689. doi:10.1001/archsurg.1974.01350290049008

Out of 246 machine-preserved human cadaveric kidneys, 83 (34%) had an early posttransplant nonfunction. Early posttransplant function was classified as F (immediate and continuing good function), FAR (immediate good function followed by accelerated rejection), SF (slow initial function), and NF (nonfunction).

Early function class NF was related largely to the duration of hemodialysis prior to transplantation and to the presence and degree of recipient presensitization, as determined by antibody-against-panel (AbAP) assays. Early function class NF kidneys also were more frequent in second than in first transplants. The numbers and specificities of HL-A antigens mismatched and machine perfusion characteristics (flow and pressure) were essentially the same for NF and F kidneys.

Belzer FO, Kountz SL:  Preservation and transplantation of human cadaver kidneys: A two-year experience . Ann Surg 173:394-404, 1970.Article
Beizer FO, et al:  Preservation and transplantation of human cadaver kidneys . Transplantation 14:363-367, 1972.Article
Lucas ZJ, et al:  Early renal transplant failure associated with subliminal sensitization . Transplantation 10:522-529, 1970.Article
Lucas ZJ:  An assay for antibodies to histocompatability antigens based on inhibition of radioiodine-labeled antibody binding . Transplantation 10:512-521, 1970.Article