[Skip to Content]
Sign In
Individual Sign In
Create an Account
Institutional Sign In
OpenAthens Shibboleth
[Skip to Content Landing]
July 1974

Autogenous Vein Grafts in Experimental Canine AtherosclerosisTheir Fate in the Abdominal Aorta and Peripheral Arteries

Author Affiliations

Bronx, NY
From the Vascular Research Laboratory, Surgical Department, Montefiore Hospital and Medical Center (Drs. Haimovici and Maier), and Albert Einstein College of Medicine (Dr. Haimovici), Bronx, NY.

Arch Surg. 1974;109(1):95-102. doi:10.1001/archsurg.1974.01360010073018

The fate of autogenous vein grafts inserted into the abdominal aorta and peripheral arteries was studied in experimentally induced canine atherosclerosis. The grafts in the abdominal aorta developed atherosclerotic changes, became dilated, and, in most instances, were surrounded by a moderate to severe fibrous reaction. Microscopically, all three coats of the vein were involved in variable degrees with characteristic morphologic and lipid degenerative changes. The grafts implanted by end-to-side anastomosis into peripheral arteries (femoral, carotid) displayed minimal or no atheromatous changes while those implanted by end-to-end anastomosis become stenosed or occluded by organized thrombi. Among the factors that may contribute to venous atherogenesis are the morphologic changes, turbulence, increased pressure, and filtration factors. When veins are placed artificially in the arterial tree, other factors than the tissue itself appear responsible for the morphologic and lipid degenerative changes.

Beebe HG, Clark WF, DeWeese JA:  Atherosclerotic change occurring in an autogenous venous arterial graft . Arch Surg 101:85-88, 1970.Article
Davidson ED, DePalma RG:  Atherosclerotic aneurysm occurring in an autogenous vein graft . Am J Surg 124:112-114, 1972.Article
Ejrup B, Hiertonn T, Moberg A:  Atheromatous changes in autogenous venous grafts: Functional and anatomical aspects: Case report . Acta Chir Scand 121:211-218, 1961.
Szilagyi DE, et al:  Biologic fate of autogenous vein implants as arterial substitutes: Clinical, angiographic and histopathologic observations in femoropopliteal operations for atherosclerosis . Ann Surg 178:232-246, 1973.Article
Friedman M:  Spontaneous atherosclerosis and experimental thromboatherosclerosis: Effect of arterial and venous environments . Arch Pathol 76:571-577, 1963.
Penn I, et al:  Evaluation of the development of atheroarteriosclerosis in autogenous venous grafts inserted into the peripheral arterial system . Circulation 31 ( (suppl 1) ):192-196, 1965.Article
Sako Y:  Susceptibility of autogenous vein grafts to atheromatous degeneration . Surg Forum 12:247-249, 1961.
Sako Y:  Effects of turbulent blood flow and hypertension on experimental atherosclerosis . JAMA 179:36-40, 1962.Article
Scott HW Jr, et al:  Experimental atherosclerosis in autogenous venous grafts . Arch Surg 101:677-682, 1970.Article
Wyatt AP, Gonzales IE:  Atheromatous lesions in arterialized vein grafts . Br J Surg 56:193-199, 1969.Article
Abell LL, et al:  Simplified method of the estimation of total cholesterol in serum and demonstration of its specificity . J Biol Chem 145:357-366, 1952.
Haimovici H, Maier N:  Correlative study of degree of canine experimental coronary atherosclerosis with that of other visceral and major systemic arteries . J Cardiovasc Surg 14:463-477, 1973.
Schenk EA, Penn I, Schwartz S:  Experimental atherosclerosis in the dog . Arch Pathol 80:102-109, 1965.
Steiner A, Kendall FE:  Atherosclerosis and arteriosclerosis in dogs following ingestion of cholesterol and thiouracil . Arch Pathol 42:433-444, 1946.
Geiringer E:  Venous atheroma . Arch Pathol 48:410-420, 1949.
Haimovici H:  Atherosclerosis: A multifaceted challenge . Ann NY Acad Sci 149:895-897, 1968.Article
Carrel A:  Graft of the vena cava on the abdominal aorta . Ann Surg 52:462-470, 1910.Article
Carrel A, Guthrie CC:  Uniterminal and biterminal venous transplantations . Surg Gynecol Obstet 2:266-286, 1906.
Chatterjee KN, Warren R, Gore I:  Long-term functional and histologic fate of arteriotomy patches of autogenous arterial and venous tissue: Observations on "arterialization." J Surg Res 4:106-110, 1964.Article
Jones M, et al:  Lesions observed in arterial autogenous vein grafts: Light and electron microscopic evaluation . Circulation 48( (suppl 3) ):198-210, 1973.
Nabatoff RA, Touroff ASW, Gross M:  Four-year studies concerning the fate of exerpimental vena cava autografts used to bridge aortic defects . Surg Gynecol Obstet 101:20-27, 1955.
Schmitz EJ, et al:  The influence of diameter disproportion and of length on the incidence of complications in autogenous venous grafts in the abdominal aorta . Surgery 33:190-206, 1953.
Steinman C, Alpert J, Haimovici H:  Inferior vena cava bypass grafts . Arch Surg 93:747-754, 1966.Article
Haimovici H, Maier N:  Role of the arterial wall in atherogenesis . Arch Surg 82:1-7, 1961.Article
Haimovici H, Maier N:  Role of arterial tissue susceptibility in experimental canine atherosclerosis . J Atheroscler Res 6:62-74, 1966.Article
Haimovici H, Maier N:  Experimental canine atherosclerosis in autogenous abdominal aortic grafts implanted into the jugular vein . Atherosclerosis 13:375-384, 1971.Article
Anitschkow N:  Experimental arteriosclerosis in animals , in Cowdry EV (ed): Arteriosclerosis . New York, Macmillan Co, 1933, 298-299.
Wilens SL:  The experimental production of lipid deposition in excised arteries . Science 114:389-393, 1951.Article