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August 1974

Peptic Ulcer Disease in the Transplant Recipient

Author Affiliations

From the Department of Surgery, University of Minnesota, Minneapolis.

Arch Surg. 1974;109(2):193-197. doi:10.1001/archsurg.1974.01360020055011

Thirty of 377 patients gave evidence of peptic ulcer disease prior to renal transplantation. Prophylactic vagotomy with pyloroplasty or antrectomy was performed on 19 of these patients prior to transplantation, and 14 of 19 are well with transplants seven to 61 months later; only three of these patients have had posttransplant ulcer complications. No planned prophylactic operation was performed in 11 patients; nine of these patients bled in the pre- or post-transplant period. Only three of 347 patients without pretransplant evidence of ulcer bled in the posttransplant period. None of the patients with vagotomy-antrectomy showed evidence of recurrent bleeding, but patients with active ulcer disease pretransplant some-times had recurrences after vagotomy-pyloroplasty. One can conclude that pretransplant correction of the ulcerogenic tendency should be carried out and that antrectomy should be considered if active ulcers are present in the uremic transplant candidate.

Dekkers CPM, et al:  Upper gastrointestinal complications and gastric secretion studies in advanced renal insufficiency , abstracted. Arch Fr Mal App Dig 61:273c, 1972.
Shepherd AMM, Stewart WK, Wormoly KG:  Peptic ulceration in chronic renal failure . Lancet 1:1357-1359, 1973.Article
Levin E, et al:  The variability and periodicity of the nocturnal gastrin secretion in normal individuals . Gastroenterology 10:939-951, 1948.
Aoyagi T, Summerskill WHJ:  Gastric secretion with ulcerogenic islet cell tumors . Arch Intern Med 117:667-672, 1966.Article
Goldstein H, et al:  Gastric acid secretion in patients undergoing chronic dialysis . Arch Intern Med 120:645-653, 1967.Article
Koman MG, Laver MC:  Hypergastrinae mix in chronic renal failure . Br Med J 1:209-210, 1972.Article
Durkin MG, Essig LJ, Nolph KD:  Gastrin removal during peritoneal dialysis , abstracted. Clin Res 19:657, 1971.
Pendras JP, Erikson RV:  Hemodialysis: A successful therapy of chronic uremia . Ann Intern Med 64:293-311, 1966.Article
McLeod LE, et al:  Intermittent hemodialysis in terminal chronic renal failure . Can Med Assoc J 94:318-327, 1966.
Barreras RF, Donaldson RM Jr:  Role of calcium in gastric hypersecretion, parathyroid adenoma and peptic ulcer . N Engl J Med 276:1122-1124, 1967.Article
Starzl TE:  Postoperative care and surgical complications , in Starzl TE (ed): Experience in Renal Transplantation . Philadelphia, WB Saunders Co, 1964, pp 116.
Hadjiyannakis EJ, et al:  Gastrointestinal complications after renal transplantation . Lancet 2:781-785, 1971.Article
Lewicki AM, Saito S, Merrill JP:  Gastrointestinal bleeding in the renal transplant patient . Radiology 102:533-537, 1972.Article
Moore TC, Hume DM:  The period and nature of hazard in clinical renal transplantation . Ann Surg 170:1-11, 1969.Article
Gordon EM, Johnson AG, Williams G:  Gastric assessment of prospective renal transplant patients . Lancet 1:226-228, 1972.Article
Simmons RL, Kjellstrand CM, Najarian JS:  Section II: Technique, complications and results , in Najarian JS, Simmons RL (eds): Transplantation . Philadelphia, Lea & Febiger, 1972, pp 445-495.