[Skip to Content]
Sign In
Individual Sign In
Create an Account
Institutional Sign In
OpenAthens Shibboleth
[Skip to Content Landing]
February 1976

Energy Metabolism Following Thermal Burns

Author Affiliations

From the Department of Surgery, University of Arkansas Medical Center, Little Rock.

Arch Surg. 1976;111(2):181-185. doi:10.1001/archsurg.1976.01360200087017

• Partitional calorimetry was performed on burned rats with and without excision of the adrenal medullae; animals were housed at ambient temperatures of 20 and 28 C. Rates of excretion of urinary nitrogen were determined for the 12 hours before calorimetry runs. Covering the burn wound with polyethylene returned the evaporative heat loss to normal and resulted in a corresponding decrease in the rate of heat production. Excision of the adrenal medullae resulted in chronic hypothermia of burned rats housed at 20 C. The highest rate of excretion of urinary nitrogen occurred in burned rats with intact adrenal medullae housed at 20 C; this excretion rate was significantly reduced when similar animals were housed at 28 C. The net effect of preventing evaporative heat loss from the wounds of burned rats is the same as that of reducing dry heat loss by elevation of the ambient temperature. Both result in a reduction in the rate of heat production.

(Arch Surg 111:181-185, 1976)

Caldwell FT, Hammel HT, Dolan F:  A calorimeter for simultaneous determination of heat production and heat loss in the rat . J Appl Physiol 21:1665-1671, 1966.
Hardy JD, DuBois EF:  Technic of measuring radiation and convection . J Nutr 15:461-475, 1938.
Caldwell FT:  Metabolic response to thermal trauma: II. Nutritional studies with rats at two environmental temperatures . Ann Surg 155:119-126, 1962.Article
Barr PO, Birke G, Liljedahl SO, et al:  Oxygen consumption and water loss during treatment of burns with warm dry air . Lancet 1:164-168, 1968.Article
Davies JWL, Liljedahl SO, Birke G:  Protein metabolism in burned patients treated in a warm (32 C) or cool (22 C) environment . Injury 1:43-56, 1969.Article
Vogt M:  Plasma adrenaline and release ACTH in normal and demedullated rats . J Physiol 118:588-594, 1952.
Stolwijk JA, Hardy JD:  Partitional calorimetric studies of responses of man to thermal transients . J Appl Physiol 21:967-977, 1966.
Depocas F:  Biochemical changes in exposure and acclimation to cold environments . Br Med Bull 17:25-31, 1961.
Harrison TS, Seaton JF, Feller I:  Relationship of increased oxygen consumption to catecholamine excretion in thermal burns Ann Surg 165:169-172, 1967.Article
Zawacki BE, Spitzer KW, Mason AD, et al:  Does increased evaporative water loss cause hypermetabolism in burned patients? Ann Surg 171:236-240, 1970.Article
Neely WA, Petro AB, Holloman GH, et al:  Researches on the cause of burn hypermetabolism . Ann Surg 179:291-294, 1974.Article
Goodall M, Stone C, Haynes BW:  Urinary output of adrenaline and noradrenaline in severe thermal burns . Ann Surg 145:479-487, 1957.Article
Birke G, Carlson LA, VonEuler US, et al:  Studies on burns: XII. Lipid metabolism, catecholamine excretion, basal metabolic rate, and water loss during treatment of burns with warm dry air . Acta Chir Scand 138:321-333, 1972.
Wilmore DW, Long JM, Mason AD, et al:  Catecholamines: Mediator of the hypermetabolic response to thermal injury . Ann Surg 180:653-669, 1974.Article
Cooper KE, Cranston WI, Snell ES:  Temperature regulation during fever in man . Clin Sci 27:345-356, 1964.
DuBois EF: Fever and the Regulation of Body Temperature . Springfield, Ill, Charles C Thomas Publisher, 1948.
Hsieh ACL, Carlson LD:  Role of adrenaline and noradrenaline in chemical regulation of heat production . Am J Physiol 190:243-246, 1957.