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Article
September 1976

Transient Bile Duct ObstructionResponse of Serum Bilirubin and Alkaline Phosphatase Levels in the Rat

Author Affiliations

From the Laboratoire de Chirurgie Expérimentale and Unité de Chirurgie Hépato-Biliaire, Université Paris-Sud, Hôpital Paul Brousse, Villejuif, France.

Arch Surg. 1976;111(9):1017-1020. doi:10.1001/archsurg.1976.01360270089017
Abstract

• The immediate evolution of changes in serum bilirubin and alkaline phosphatase levels during and after brief temporary occlusion (12 hours or less) of the main bile duct was studied in the rat.

Transient obstruction of the main bile duct of more than one hour was characterized by a simultaneous increase in serum levels of both bilirubin and alkaline phosphatase. The time required for return to normal values was less for bilirubin than the duration of a brief obstruction and was more prolonged for alkaline phosphatase than the duration of obstruction. In obstruction of four or more hours, it was rare to find an isolated elevation of serum bilirubin; this occurred when the control value for alkaline phosphatase levels was low and their relative increase was obscured. Thus, an isolated increase in the serum bilirubin level is infrequently compatible with obstruction of the bile duct, even when transient and of brief duration. Conversely, isolated elevation of serum alkaline phosphatase levels in an acute abdominal syndrome may indicate relieved biliary obstruction.

(Arch Surg 111:1017-1020, 1976)

References
1.
Corlette MB, Bismuth H:  Acute cholecystitis and jaundice . Arch Surg 106:829-832, 1973.Article
2.
Weber AP, Schalm C:  Quantitative separation and determination of bilirubin and conjugated bilirubin in human serum . Clin Chim Acta 7:805-810, 1962.Article
3.
Chabrol E, Maximin M, Busson A:  Le méchanism de l'ictère dans l'obstruction du canal cholédoque . Presse Med 1:892-894, 1931.
4.
Alican F, Hardy JD:  Lymphatic transport of bile pigments and alkaline phosphatase in experimental common duct obstruction . Surgery 52:366-371, 1962.
5.
Cameron GR, Hasan SM:  Disturbances of structure and function as the result of biliary obstruction . J Pathol Bacteriol 75:333-348, 1958.Article
6.
Cameron GR, Oakley CL:  Ligation of the common bile duct . J Pathol 35:769-791, 1932.Article
7.
Kaplan MM, Righetti A:  Induction of rat liver alkaline phosphatase: The mechanism of the serum elevation in bile duct obstruction . J Clin Invest 49:508-516, 1970.Article
8.
Birns M, Masek N, Auerbach O:  The effects of experimental acute biliary obstruction and release on the rat liver: A histochemical study . Am J Pathol 40:95-111, 1962.
9.
Righetti A, Kaplan MM:  Disparate responses of serum and hepatic alkaline phosphatase and 5′ nucleotidase to bile duct obstruction in the rat . Gastroenterology 62:1034-1039, 1972.
10.
Snell AM, Greene CH, Rowntree LG:  Diseases of the liver: II. A comparative study of certain tests for hepatic function in experimental obstructive jaundice . Arch Intern Med 36:248-285, 1925.Article
11.
Börnig H, Horn A, Müller W:  Zum Mechanismus der Aktivitätsanderung der Alkalischen Phosphatase in Leber und Darm der Ratte nach Ligature des Ductus Choledochus . Acta Biol Med Ger 22:537-549, 1969.
12.
Aronsen KF:  Liver function studies during and after complete extrahepatic biliary obstruction in the dog . Acta Chir Scand , (suppl 275) , 1961, pp 73-75.
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