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January 1977

Perfusate Composition in Renal Preservation

Author Affiliations

From Unit II Surgery, Veterans Administration Hospital, St Louis.

Arch Surg. 1977;112(1):67-68. doi:10.1001/archsurg.1977.01370010069014

• Between July 1972 and November 1975, a total of 74 cadaver kidneys were preserved by hypothermic pulsatile perfusion using the Belzer L1-400. The initial 45 kidneys were perfused with cryoprecipitated plasma (CPP) and the subsequent 29 kidneys with plasma protein fraction (PPF). In the CPP group, 24 kidneys (53.3%) achieved immediate function, and graft survival at one and six months was 68.8% and 42.2%, respectively. In the PPF group, 14 kidneys (48.2%) achieved immediate function, with graft survival at one and six months 65.5% and 48.2%, respectively. The theoretical advantages of PPF include freedom from risk of hepatitis, absence of gamma globulin with its potential for immunologic damage to the kidney, and time saved in preparation. Our clinical experience shows that PPF is as effective as CPP as a perfusate in preservation of kidneys for transplantation.

(Arch Surg 112:67-68, 1977)

Belzer FO, Kountz SL:  Preservation and transplantation of human cadaver kidneys: A two-year experience . Ann Surg 172:394-403, 1970.Article
Johnson RWG, Anderson M, Ilear CTG, et al:  Evaluation of a new perfusion solution for kidney preservation . Transplantation 13:270-275, 1972.Article
Filo RS, Dickson LG, Sula EA, et al:  Immunologic injury induced by exvivo perfusion of canine renal autografts . Surgery 76:88-100, 1974.
Hink JH Jr, Hidalgo J, Seeberg VC, et al:  Preparation and properties of a heat-treated human plasma protein fraction . Vox Sand 2:174-186, 1957.Article
Mendez-Picon G, Belle C. Pierce JD, et al:  Use of plasma protein fraction in preservation of cadaveric kidneys . Surgery 79:364-369, 1976.
Wilson RE.  Transplantation . Surg Gynecol Obstet 142:219-224, 1976.
Cross DE, Whittier FC, Cuppage FE, et al:  Hyperacute rejection of renal allografts following pulsatile perfusion with a perfusate containing specific antibody . Transplantation 17:626-629, 1974.Article