• Of 42 critically ill patients with toxic megacolon, 31 required emergency surgery, and 11 were treated without operation. Of the 11 patients treated by medical measures alone, there were two deaths (18%): one early, secondary to undiagnosed colonic perforation, and one late death from recurrent ulcerative colitis. Nine of ten survivors (90%) experienced continued morbidity, and five (50%) required subsequent elective surgery. Thirty-one patients required emergency operation for failure of medical treatment (19), colonic perforation (ten), and uncontrolled hemorrhage (two). Early and late morbidity was 74% (two-thirds occurring after subtotal colectomy and ileostomy). Surgical mortality was 19% (8% over the last ten years).
(Arch Surg 112:518-522, 1977)
Sirinek KR, Tetirick CE, Thomford NR, Pace WG. Total Proctocolectomy and IleostomyProcedure of Choice for Acute Toxic Megacolon. Arch Surg. 1977;112(4):518-522. doi:10.1001/archsurg.1977.01370040170026