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April 1978

Primary Hyperparathyroidism and Peptic Ulcer Disease

Author Affiliations

From the Mayo Clinic and Mayo Foundation, Rochester, Minn.

Arch Surg. 1978;113(4):384-386. doi:10.1001/archsurg.1978.01370160042005

• To determine whether primary hyperparathyroidism is related to peptic ulcer disease, we evaluated 46 cases of concomitant primary hyperparathyroidism and peptic ulcer disease. Among these patients, there was no sex preponderance. The pathologic findings at parathyroid surgery, as well as the features of peptic ulcer disease, were the same as in patients with primary hyperparathyroidism or with peptic ulcer disease alone. The ulcer symptoms of 58% of the patients with adequate follow up improved after parathyroidectomy. Sixty-six percent of the patients who had active peptic ulcer disease at surgery improved as compared with only 44% of the patients who had complicated peptic ulcer disease. None of the factors studied (age, sex, serum calcium and serum parathyroid hormone levels, location, and duration of ulcer) had any effect on the peptic ulcer symptoms after parathyroidectomy. Our results and a critical review of the experimental and clinical literature suggest that the association between primary hyperparathyroidism and peptic ulcer disease is no more than coincidental.

(Arch Surg 113:384-386, 1978)

Boyd JD, Milgram JE, Stearns G:  Clinical hyperparathyroidism . JAMA 93:684-688, 1929.Article
Gutman AB, Swenson PC, Parsons WB:  The differential diagnosis of hyperparathyroidism . JAMA 103:87-94, 1934.Article
Pemberton JdeJ, Geddie KB:  Hyperparathyroidism . Ann Surg 92:202-211, 1930.Article
Rogers HM:  Parathyroid adenoma and hypertrophy of the parathyroid glands . JAMA 130:22-28, 1946.Article
McGeown MG, Connell AM:  Gastric function in primary hyperparathyroidism in man . Ir J Med Sci 144:217-226, 1975.Article
Wilder WT, Frame B, Haubrich WS:  Peptic ulcer in primary hyperparathyroidism: An analysis of 52 cases . Ann Intern Med 55:885-893, 1961.Article
White FW:  The incidence of gastroduodenal ulcer , in Sandweiss DJ (ed): Peptic Ulcer: Clinical Aspects, Diagnosis, Management . Philadelphia, WB Saunders Co, 1951, pp 185-195.
Barreras RF, Donaldson RM Jr:  Effects of induced hypercalcemia on human gastric secretion . Gastroenterology 52:670-675, 1967.
Palmer WL:  The therapy of peptic ulcer. Part II. Radiation therapy , in Bockus HL (ed): Gastroenterology , ed 3. Philadelphia, WB Saunders Co, 1974, vol 1, pp 710-719.
Hallenbeck GA:  The natural history of duodenal ulcer disease . Surg Clin North Am 56:1235-1242, 1976.
Barreras RF, Donaldson RM Jr:  Role of calcium in gastric hypersecretion, parathyroid adenoma and peptic ulcer . N Engl J Med 276:1122-1124, 1967.Article
Murphy DL, Goldstein H, Boyle JD, et al:  Hypercalcemia and gastric secretion in man . J Appl Physiol 21:1607-1610, 1966.
Reeder DD, Jackson BM, Ban J, et al:  Influence of hypercalcemia on gastric secretion and serum gastrin concentrations in man . Ann Surg 172:540-546, 1970.Article
Wilson SD, Singh RB, Kalkhoff RK, et al:  Does hyperparathyroidism cause hypergastrinemia? Surgery 80:231-237, 1976.
Smallwood RA:  Effect of intravenous calcium administration on gastric secretion of acid and pepsin in man . Gut 8:592-598, 1967.Article
Kaplan EL, Peskin GW, Deneney C, et al:  Ulcer disease, metabolic alkalosis and hyperparathyroidism: A mechanism of interrelationship? Ann Surg 180:549-555, 1974.Article