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March 1979

Gastric Tissue Prostaglandin LevelsEffect of Vagotomy

Author Affiliations

From the Department of Surgery, Veterans Administration Hospital, and the University of California, San Diego.

Arch Surg. 1979;114(3):331-332. doi:10.1001/archsurg.1979.01370270101019

• To determine tissue prostaglandin levels in antrum and fundus and to examine the effect of vagotomy and distention on tissue prostaglandin levels, truncal and parietal cell vagotomies were performed on rats that were killed at 2, 4, and 6 weeks postoperatively with antral and fundic prostaglandin E1 levels being determined. The fundus has considerably higher levels of prostaglandin than the antrum. No differences after any type of vagotomy however, were noted. It cannot be concluded from this study that increased prostaglandin levels result from vagotomy.

(Arch Surg 114:331-332, 1979)

Robert A, Nezamis JE, Phillips JP:  Inhibition of gastric secretion by prostaglandin . Am J Dig Dis 12:1073-1076, 1967.Article
Cohen MM, Pollett JM:  Prostaglandin E2 prevents aspirin and indomethacin damage to human gastric mucosa . Surg Forum 27:440-441, 1976.
Wilson DE, Winnan G, Quertaimas J, et al:  Effects of an orally administered prostaglandin analog (16, 16-dimethyl prostaglandin E2) on human gastric secretion . Gastroenterology 69:607-611, 1975.
Robert A, Schultz JR, Nezamis JE, et al:  Gastric antisecretory and anti-ulcer properties of PGE2, 15-methyl PGE2, and 16, 16-dimethyl PGE2 . Gastroenterology 70:359-370, 1976.
Saik RP, Greenburg AG, Farris JM, et al:  The practicality of the Congo red test . Am J Surg 132:144-149, 1976.Article
Jaffe BM, Behrman HR: Methods of Hormone Radioimmunoassay . New York, Academic Press Inc, 1974,  chap 2 , p 19.
Robert A, Nezamis JE, Phillips JP:  Effect of prostaglandin E1 on gastric secretion and ulcer formation in the rat . Gastroenterology 55:4-7, 1968.
Nezamis JE, Robert A, Stowe DF:  Inhibition by prostaglandin E, of gastric secretion in the dog . J Physiol 218:369-383, 1971.
Bolton DP, Palmer D, Cohen MM:  Effect of the E2 prostaglandin on gastric mucus production in rats . Surg Forum 27:402-403, 1976.