[Skip to Content]
Sign In
Individual Sign In
Create an Account
Institutional Sign In
OpenAthens Shibboleth
[Skip to Content Landing]
June 1980

Prognostic Value of Lymph Node Dissection in Malignant Melanoma

Author Affiliations

From the Departments of Surgical Oncology (Drs Karakousis and Seddiq) and Biostatistics (Mr Moore), New York State Department of Health, Roswell Park Memorial Institute, Buffalo.

Arch Surg. 1980;115(6):719-722. doi:10.1001/archsurg.1980.01380060021006

• Retrospective review of 199 patients with malignant melanoma who had regional node dissection showed that the median survival rates of patients with histologically negative nodes was more than threefold higher than that of patients with histologically positive regional nodes. In the patients with positive nodes, survival was related to the number of nodes involved. Patients with one, two, and three or more positive lymph nodes had a tumor-free five-year survival rate of 41%, 30%, and 18%. Patients who required regional node dissection for positive palpable nodes in one month, one year, or longer than one year from the excision of the primary tumor had a median survival of 21.5, 22, and 44 months.

(Arch Surg 115:719-722, 1980)

Veronesi V, Adamus J, Bandiera DC, et al:  Inefficacy of immediate node dissection in stage I melanoma of the limbs . N Engl J Med 297:627-637, 1977.Article
Moore GE, Gerner RE:  Malignant melanoma . Surg Gynecol Obstet 132:427-436, 1971.
Goldsmith HS:  The debate over immediate lymph node dissection in melanoma . Surg Gynecol Obstet 148:403-405, 1979.
Balch CM, Murad TM, Soong SJ, et al:  Tumor thickness as a guide to surgical management of clinical stage I melanoma patients . Cancer 43:883-888, 1979.Article
Balch CM, Murad TM, Soong SJ, et al:  Multifactorial analysis of melanoma: Prognostic histopathological features comparing Clark's and Breslow's staging method . Ann Surg 188:732-742, 1978.Article
Pickren JW:  Nodal clearance and detection . JAMA 231:969-971, 1975.Article
Fortner JG, Booher RG, Pack GT:  Results of groin dissection for malignant melanoma in 220 patients . Surgery 55:485-494, 1964.
Wanebo HJ, Woodruff J, Fortner JG:  Malignant melanoma of the extremities: A clinicopathologic study using levels of invasion (microstage) . Cancer 35:666-676, 1975.Article
Das Gupta TK:  Results of treatment of 269 patients with primary cutaneous melanoma: A five-year prospective study . Ann Surg 186:201-209, 1977.Article
Gumport SL, Meyer HW:  Treatment of 126 cases of malignant melanoma: Long term results . Ann Surg 150:989-992, 1959.Article
Gumport SL, Harris MN:  Results of regional lymph node dissection for melanoma . Ann Surg 179:105-108, 1974.Article
Guiss LW, MacDonald I:  The role of radical regional lymphadenectomy in treatment of melanoma . Am J Surg 104:135-142, 1962.Article
McNeer G, Das Gupta T:  Life history of melanoma . Am J Roentgenol 93:686-694, 1965.
Mundth ED, Guraluich EA, Raker JW:  Malignant melanoma: A clinical study of 427 cases . Ann Surg 162:15-28, 1965.Article
Conrad FG:  Treatment of malignant melanoma . Arch Surg 104:587-593, 1972.Article
Cohen MH, Ketcham AS, Felix EL, et al:  Prognostic factors in patients undergoing lymphadenectomy for malignant melanoma . Ann Surg 186:635-642, 1977.Article
Fortner JG, Woodruff J, Schottenfeld D, et al:  Biostatistical basis of elective node dissection for malignant melanoma . Ann Surg 186:101-103, 1977.Article