[Skip to Content]
Sign In
Individual Sign In
Create an Account
Institutional Sign In
OpenAthens Shibboleth
[Skip to Content Landing]
Article
March 1981

Exogenous Gastrin in Rhesus MonkeysThe Effect of 50% Distal Small-Bowel Resection on Its Rate of Disappearance

Author Affiliations

From the Department of Surgery, University of Chicago (Drs Mackie, Lewis, and Moossa), and the Gastrointestinal Unit, Mayo Clinic, Rochester, Minn (Dr Go).

Arch Surg. 1981;116(3):297-300. doi:10.1001/archsurg.1981.01380150025006
Abstract

• The rate of disappearance from the circulation of exogenous heptadecapeptide gastrin was studied before and after 50% distal small-bowel resection in four rhesus monkeys. For each study, venous blood samples were drawn during, and at frequent intervals after, a one-hour peripheral venous infusion of synthetic human gastrin 1 given at a constant rate within the range of 0.4 to 2.4 μg/hr/kg of body weight. The rate of disappearance of infused gastrin was not affected by small-bowel resection (mean half-time before operation, 2.50 minutes; mean half-time after operation, 2.47 minutes). These data indicate that in the rhesus monkey, the rate of catabolism of exogenous gastrin is not decreased after distal small-bowel resection, and indicate that other mechanisms are responsible for the hypergastrinemia and gastric acid hypersecretion observed in this animal model.

(Arch Surg 1981;116:297-300)

References
1.
Landor JH, Baker WK:  Gastric hypersecretion produced by massive small bowel resection in dogs . J Surg Res 1964;4:518-522.Article
2.
Osborne MP, Frederick PL, Sizer JS, et al:  Mechanism of gastric hypersecretion following massive intestinal resection: Clinical and experimental observations . Ann Surg 1966;164-622-632.Article
3.
Reul GJ, Ellison EH:  Effect of 75% distal small bowel resection on gastric secretion . Am J Surg 1966;111:772-776.Article
4.
Windsor CWO, Fejfar J, Woodward DAK:  Gastric secretion after massive small bowel resection . Gut 1969;10:779-786.Article
5.
Caridis DT, Roberts M, Smith G:  The effect of small bowel resection on gastric acid secretion in the rat . Surgery 1969;65:292-297.
6.
Ruderman RL, Kamel II:  Intestinal control of gastric hyperacidity . Surg Gynecol Obstet 1972;134:637-639.
7.
Avery GB, Randolph JG, Weaver T:  Gastric response to specific diseases in infants . Pediatrics 1966;38:874-878.
8.
Fielding JF, Cooke WT, Williams JA:  Gastric acid secretion in Crohn's disease in relation to disease activity and bowel resection . Lancet 1971;1:1106-1107.Article
9.
Klein MS, Winawer SJ:  Intermittent basal gastric hypersecretion following small bowel resection . Am J Gastroenterol 1974;61:470-475.
10.
Moossa AR, Hall AW, Skinner DB, et al:  Effect of 50% small bowel resection on gastric secretory function in rhesus monkeys . Surgery 1976;80:208-213.
11.
Junghanns K, Kaess H, Encke A:  The influence of resection on the small intestine gastrin levels . Surg Gynecol Obstet 1975;140:27-29.
12.
Wickbom G, Landor JH, Bushkin FL, et al:  Changes in canine gastric acid output and serum gastrin levels following massive small intestine resection . Gastroenterology 1975;69:448-452.
13.
Bowen JC, Paddack GL, Bush JC, et al:  Comparison of gastric responses to small intestinal resection and bypass in rats . Surgery 1978;83:402-405.
14.
Straus E, Gerson CD, Yalow RS:  Hypersecretion of gastrin associated with the short bowel syndrome . Gastroenterology 1974;66:175-180.
15.
Becker HD, Reeder DD, Thompson JC:  Extraction of circulating endogenous gastrin by the small bowel . Gastroenterology 1973;65:903-906.
16.
McGuigan JE, Landor JH, Wickbom G:  Changes in acid secretion, gastrin release, and gastrin metabolism after small intestine resection, abstracted . Gastroenterology 1974;66:742.
17.
Temperley JM, Stagg BH, Wyllie JH:  Disappearance of gastrin and pentagastrin in the portal circulation . Gut 1971;12:372-376.Article
18.
Yalow RS, Berson SA:  Radioimmunoassay of gastrin . Gastroenterology 1970;58:1-14.
19.
Walsh JH, Debas HT, Grossman MI:  Pure big gastrin: Immunochemical properties, disappearance half-time, and acid stimulating action in dogs . J Clin Invest 1974;54:477-485.Article
20.
Schrumpf E, Semb LS:  The metabolic clearance rate of half-life of synthetic human gastrin in dogs . Scand J Gastroenterol 1973;9:203-207.
21.
Schrumpf E, Semb LS, Void H:  Metabolic clearance and disappearance rates of synthetic human gastrin in man . Scand J Gastroenterol 1973;8:731-734.
22.
Woussen-Cole MC, DeGraef J:  Relationship between disposal rate of exogenous gastrin and sensitivity to stimulation of acid secretion by this hormone in dogs . Am J Dig Dis 1977;22:132-136.Article
23.
McGuigan JE, Isaza J, Landor JH:  Relationships of gastrin dose, serum gastrin, and acid secretion . Gastroenterology 1971;61:659-666.
24.
Reeder DD, Jackson BM, Brandt EN Jr, et al:  Rate and pattern of disappearance of exogenous gastrin in dogs . Am J Physiol 1972;222:1571-1574.
25.
Straus E, Yalow RS:  Studies on the distribution and degradation of heptadecapeptide, big and big big gastrin . Gastroenterology 1974;66:936-943.
26.
Walsh JH, Isenberg JI, Ansfield J, et al:  Clearance and acid-stimulating action of human big and little gastrins in duodenal ulcer subject . J Clin Invest 1976;57:1125-1131.Article
27.
Makhlouf GM:  Potency of stimulants and half-life of hormonal peptides in species of different body size . Gastroenterology 1973;65:170-173.
28.
Boniface J, Picone D, Schebalin M, et al:  Clearance rate, half-life, and secretory potency of human gastrin-17-1 in different species . Gastroenterology 1976;71:291-294.
29.
Clendinnen BG, Reeder DD, Brandt EN Jr, et al:  Effect of nephrectomy on the rate and pattern of the disappearance of exogenous gastrin in dogs . Gut 1973;14:462-467.Article
30.
Debas HT, Grossman MI: Hepatic inactivation of gastrointestinal hormones. Read before the Fifth World Congress of Gastroenterology, Mexico City, Oct 13, 1974.
31.
Strunz UT, Thompson MR, Elashoff J, et al:  Hepatic inactivation of gastrins of various chain lengths in dogs . Gastroenterology 1978;74:550-553.
32.
Thompson JC, Rayford PL, Ramus NI, et al:  Patterns of release and uptake of heterogenous forms of gastrin , in Thompson JC (ed): Gastrointestinal Hormones . Austin, Tex, University of Texas Press, 1975, pp 125-151.
33.
Thompson JC, Reeder DD, Davidson WD, et al:  Effect of hepatic transit of gastrin, pentagastrin and histamine measured by gastric secretion and by assay of hepatic vein blood . Ann Surg 1969;170:493-503.Article
34.
Thompson JC, Reeder DD, Davidson WD, et al:  Studies on the metabolism of gastrin , in Anderson S (ed): Nobel Symposium 16: Frontiers in Gastrointestinal Research, July 20-21, 1970 . Stockholm, Almqvist & Wikesll, 1973, pp 111-119.
35.
Yakimets WW, Bondar GF:  The effect of complete thoracic-duct lymph diversion on gastric secretion in dogs . Can J Surg 1967;10:218-222.
36.
Yakimets WW, Bondar GF:  Hormonal stimulatory mechanism producing gastric hypersection following massive small intestine resection . Can J Surg 1969;12:241-244.
37.
Clain JE, Go VLW, Malagelada J:  Inhibitory role of the distal small intestine on the gastric secretory response to meals in man . Gastroenterology 1978;74:704-707.
38.
Clain JE, Malagelada J, Go VLW, et al:  Participation of the jejunum and ileum in postprandial gastric secretion in man . Gastroenterology 1977;73:211-214.
39.
Kajiwara T, Tamura K, Suzuki T:  Follow-up studies of gastrin response after resection of the jejunum and the ileum . Ann Surg 1977;186:694-699.Article
40.
Woussen-Colle MC, Brihaye C, Limbosch JM, et al:  Effect of small bowel resection on gastrin release, catabolism and activity in dogs . J Surg Res 1976;21:225-232.Article
41.
Forsyth RP, Niew AS, Wyler F, et al:  Normal distribution of cardiac output in the unanesthetized, restrained rhesus monkey . J Appl Physiol 1968;25:736-740.
×