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Article
April 1981

Prostacyclin (Epoprostenol)Its Effect on Canine Splanchnic Blood Flow During Hemorrhagic Shock

Author Affiliations

From the Surgical Service, East Orange Veterans Administration Medical Center (Drs Seelig and Hobson, and Mr Kerr), East Orange, NJ, and the Department of Surgery, College of Medicine and Dentistry of New Jersey, New Jersey Medical School (Drs Seelig, Hobson, and Machiedo, and Mr Kerr), Newark.

Arch Surg. 1981;116(4):428-430. doi:10.1001/archsurg.1981.01380160044009
Abstract

• Prostacyclin (epoprostenol, prostaglandin I2) is a vasodilator of the splanchnic circulation during normotensive states. To confirm the persistence of its effects after hemorrhagic shock, six anesthetized, previously splenectomized, adult mongrel dogs were subjected to hemorrhagic shock using a modified Wigger's technique in which a mean arterial pressure of 30 mm Hg was maintained until 25% of the shed blood spontaneously returned. The animals were randomly resuscitated with normal saline solution or a similar volume of saline solution containing prostacyclin. Organ blood flow was calculated by measuring the distribution of radioactively tagged microspheres. During shock, blood flows to the liver, small intestine, pancreas, and carcass were reduced. During a 60-minute infusion, prostacyclin selectively caused a significant increase in hepatic arterial blood flow. This improvement in arterial blood flow may prove beneficial in the clinical management of hemorrhagic shock.

(Arch Surg 1981;116:428-430)

References
1.
Machiedo GW, Brown CS, Lavigne JE, et al:  Prostaglandin E1 as a therapeutic agent in hemorrhagic shock . Surg Forum 1973;24:12-14.
2.
Priano LL, Miller TH, Raber AL:  Use of prostaglandin E, in the treatment of experimental hypovolemic shock . Circ Shock 1974;1:221-230.
3.
Rudolph AM, Heymann MA:  Methods for studying distribution of blood flow . Circ Res 1967;21:163-184.Article
4.
Forsyth RP, Nies AS, Wyler F, et al:  Normal distribution of cardiac output in the unanesthetized rhesus monkey . J Appi Physiol 1968;25:736-741.
5.
Hobson RW, Wright CR, Zinner MJ:  Cerebral blood flow determinations by radioactive microspheres in the subhuman primate: Influence of unilateral internal carotid ligation, hypercapnic acidosis and hypocapnic alkalosis . Surgery 1976;80:230-244.
6.
Glenn TM, Raflo GT, Wagensteen SL:  Beneficial effect of prostaglandin E, and F2 in endotoxic shock . Pharmacologist 1971;13:293.
7.
McCurdy R, Nakano J:  Cardiovascular effects of prostaglandin E, . Clin Res 1966;14:428.
8.
Nakano K:  Effects of prostaglandin E1, A1, and F2 on coronary and peripheral circulations . Proc Soc Expl Biomed 1968;127:1160-1163.Article
9.
Nakano J, Cole B:  Effects of prostaglandin E, and F2a on systemic pulmonary and splanchnic circulations in dogs . Am J Physiol 1969;217:222-227.
10.
Nakano J, McCurdy JR:  Hemodynamic effects of prostaglandins E1, A1 and F2a in dogs . Proc Soc Expl Biol Med 1968;128:39-42.Article
11.
Machiedo GW, Rush BF Jr:  Effect of prostaglandin on high energy phosphate metabolism in hemorrhagic shock . Clin Res 1977;25:235A.
12.
Snedecor GW, Chochron WG: Statistical Methods , ed 6. Ames, Iowa, Iowa State University Press, 1967.
13.
Szczeklik A, Nizankowski R, Skawinski S, et al:  Successful therapy of advanced arteriosclerosis obliterans with prostacyclin . Lancet 1979;1:1111-1114.Article
14.
Szczeklik J, Szczeklik A, Nizankowski R:  Hemodynamic effects of prostacyclin in man . Adv Prostaglandin Thromboxane Res 1980;7:769-775.
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